HIVandHepatitis.com Coverage of Highlights from the
 3rd IAS Conference on HIV Pathogenesis and Treatment
 July 24 - 27, 2005, Rio de Janerio, Brazil
Note: Unless otherwise stated, all references are to the Abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment, July 24 - 27, 2005, Rio de Janerio, Brazil
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Table of Contents

Library of Posters

Articles by Topic - A to Z

Highlights of HIV Drug Resistance Studies Presented at the 3rd IAS Conference
Complications of Therapy / Adverse Events / Side Effects
Cost of HIV/AIDS Medical Care
Developing Countries
Dosing / Once-Daily Dosing (QD) / Fixed Dose Combinations
Drug Resistance
Epidemiology
Entry Inhibitors
Experimental Antiretrovirals / New Antiretrovirals
HIV Coinfection with Hepatitis B or Hepatitis C
Lipids and Metabolic Complications
Mother-to-Child Transmission (MTCT) of HIV
New Therapeutic Approaches
Non Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
Nucleoside/tide Reverse Transcriptase Inhibitors (NRTIs)
Pathogenesis
Pharmacokinetics and Drug Interactions
Prevention of HIV Infection
Protease Inhibitors (PIs) and Boosted PIs
Salvage Therapy
Sexual Transmission of HIV
Therapy for Treatment-naïve Individuals
Therapy for Treatment-experienced Individuals
Vaccines
Viral Diversity
Virological (Treatment) Failure




HIV Coinfection with Hepatitis B or Hepatitis C   

HIV-HCV Coinfected Patients Develop Liver Cancer at a Younger Age than HCV-monoinfected patients but There Is No Difference in Survival Times between the Two Groups - 8/26/05

Higher Non Nucleoside and Lower Lopinavir Levels in HIV-HCV Coinfected Patients
- 8/10/05

Safety of a Fosamprenavir/Ritonavir-containing Regimen Over 120 Weeks in HIV Positive Treatment-naïve Adults with or without hepatitis B and/or C Coinfection
- 8/01/05

Safety of Abacavir + Lamivudine-based HAART in ART-naïve HIV Positive Subjects with and without Hepatitis B and/or Hepatitis C Coinfection - 8/01/05

Pattern of Hepatotoxicity on Different Antiretroviral Regimens in HIV Patients with or without Chronic Hepatitis B or Hepatitis C - 8/01/05

Liver Disease and Not HCV Coinfection May Be Predictive of a Higher Discontinuation of HAART - 8/01/05

Experimental Antiretrovirals / New Antiretrovirals   

Experimental NNRTI TMC 120 Appears Safe and Effective as Microbicide - 8/10/05

Antiviral Activity and Safety of GW695634, a Next Generation NNRTI, in Patients with NNRTI-resistant HIV
- 8/08/05

Salvage Study of Experimental HIV Protease Inhibitor TMC-114 from Tibotec Yields Outstanding Results
- 8/01/05

GlaxoSmithKline Begins Phase III Trials of CCR5 Antagonist Aplaviroc
- 7/29/05

Dosing Study of SCH 417690, New CCR5 Receptor Antagonist from Schering-Plough
- 7/27/05

New Nucleoside Analog Reverset (D-d4FC) Shows Promise in Phase II Study of Treatment-experienced Patients
- 7/27/05

Phase 1/2a Safety and Efficacy Data of CCR5 Antagonist Maraviroc (UK-427,857)
- 7/27/05

Protease Inhibitors (PIs) and Boosted PIs   

Establishing the Clinical Cutoffs for Atazanavir and Tipranavir - 9/10/05

HIV Protease Inhibitors Have Anti-malarial Effects
- 8/22/05

Improvements in Lopinavir/Ritonavir Formulation
- 8/10/05

Higher Non Nucleoside and Lower Lopinavir Levels in HIV-HCV Coinfected Patients
- 8/10/05

Adverse Events are the Main Cause of Treatment Failure in a Multicentre Trial in Naïve Patients, comparing Zidovudine/Lamivudine vs Stavudine/Didanosine, plus Efavirenz, Nevirapine or Indinavir/Ritonavir
- 8/08/05

2-year Follow-Up of Combination Lopinavir/Ritonavir-Efavirenz - 8/08/05

Tipranavir/ritonavir Demonstrates Superior Response to Lopinavir/ritonavir, Amprenavir/ritonavir or Saquinavir/ritonavir in PI-experienced Patients
- 8/08/05

Tipranavir/ritonavir 500 mg/200 mg BID Drives Week 24 viral load <400 copies/mL When Combined with Enfuvirtide in Protease Inhibitor-experienced HIV Patients
- 8/03/05

Once-Daily Salvage Regimens for Heavily Treatment-experienced HIV-Infected Patients in the Atazanavir Early Access Program in Spain - 8/03/05

Safety of a Fosamprenavir/Ritonavir-containing Regimen Over 120 Weeks in HIV Positive Treatment-naïve Adults with or without hepatitis B and/or C Coinfection
- 8/01/05

Treatment-naïve Patients Treated with Ritonavir-boosted Saquinavir Show No Significant Resistance to Protease Inhibitors
- 7/29/05

Switching to Atazanavir from Other PI-based HAART Maintains Suppression, Results in Fewer Viral Rebounds and Improves Lipids and GI Tolerance: The SWAN Study - 7/29/05

Once-daily versus Twice-daily Lopinavir/Ritonavir in Treatment-naïve Patients: 96-week Results - 7/29/05

Immunologic Reconstitution through 6 Years in Antiretroviral-Naïve Patients Treated with Lopinavir/Ritonavir - 7/29/05


Non Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)   

Preventing Mother-to-Child Transmission (MTCT) and Nevirapine Resistance - 9/08/05

Experimental NNRTI TMC 120 Appears Safe and Effective as Microbicide
- 8/10/05

Higher Non Nucleoside and Lower Lopinavir Levels in HIV-HCV Coinfected Patients
- 8/10/05

High Rate of Virological Failure during Once-daily Therapy with Tenofovir + Didanosine 250mg + Efavirenz in Treatment-naive Patients
- 8/08/05

Adverse Events are the Main Cause of Treatment Failure in a Multicentre Trial in Naïve Patients, comparing Zidovudine/Lamivudine vs Stavudine/Didanosine, plus Efavirenz, Nevirapine or Indinavir/Ritonavir
- 8/08/05

Tenofovir in Combination with Lamivudine and Efavirenz in Treatment-naïve HIV Patients
-- 8/08/05

2-year Follow-Up of Combination Lopinavir/Ritonavir-Efavirenz
- 8/08/05

Tipranavir/ritonavir Demonstrates Superior Response to Lopinavir/ritonavir, Amprenavir/ritonavir or Saquinavir/ritonavir in PI-experienced Patients
- 8/08/05

Efficacy and Safety of Once-Daily Abacavir/Lamivudine Fixed-dose Combination + Efavirenz - 8/03/05
Nevirapine Concentration in Cervico-vaginal and Oropharyngeal Secretions - 8/03/05

Timing of Maternal and Infant Nevirapine and the Risk of Mother-to-child Transmission of HIV - 8/03/05

6-month Immunological Response with HAART-containing Nevirapine in HIV Positive Women Post-exposure to Single-dose of Nevirapine for PMTCT - 8/03/05

Switch from PI- to Sustiva-based HAART Shows No Impact of Race on Efficacy and Nervous System Symptoms - 8/03/05


Nucleoside/tide Reverse Transcriptase Inhibitors   

A New Mechanisms for NRTI Resistance: Mutations the RNase H Encoding Region - 9/08/05

Absence of K65R in Subjects Failing Tenofovir in GS934 - 9/08/05

The Effect of the M184V Mutation on HIV Replication and the Maintenance of CD4+ Counts - 9/08/05

Adverse Events are the Main Cause of Treatment Failure in a Multicentre Trial in Naïve Patients, comparing Zidovudine/Lamivudine vs Stavudine/Didanosine, plus Efavirenz, Nevirapine or Indinavir/Ritonavir
- 8/08/05

Tenofovir in Combination with Lamivudine and Efavirenz in Treatment-naïve HIV Patients
-- 8/08/05

Lack of Resistance to Tenofovir at Week 48 and Impact of Baseline Resistance Mutations on Treatment Response
- 8/08/05

Efficacy and Safety of a Once-daily Fixed-dose Combination of Abacavir/Lamivudine versus Abacavir Twice-daily and Lamivudine Once-daily as Separate Entities in Treatment-experienced Patients 
-- 8/08/05

Quadruple Nucleoside/tide Regimen of Trizivir + Tenofovir Is Effective Following Early Virologic Failure on an Initial Regimen Containing a Thymidine Analog + Lamivudine + a PI or NNRTI
- 8/08/05

Patient Satisfaction with Abacavir-Lamivudine Fixed-dose Combination (FDC) Tablet Once daily (QD) Compared with Abacavirand Lamivudine Twice-daily
- 8/08/05

Switching from Stavudine to Tenofovir Decreases Cardiovascular Risk
- 8/05/05

Tenofovir Affects Renal Function but Renal Failure Is Rare
- 8/03/05

Efficacy and Safety of Once-Daily Abacavir/Lamivudine Fixed-dose Combination + Efavirenz - 8/03/05

Routine Use of Combined Zidovudine and Nevirapine Regimen in MTCT-Plus Program - 8/03/05


Entry Inhibitors   

Salvage Therapy in Different Clinical Settings - 8/05/05

Tipranavir/ritonavir 500 mg/200 mg BID Drives Week 24 viral load <400 copies/mL When Combined with Enfuvirtide in Protease Inhibitor-experienced HIV Patients - 8/03/05




Therapy for Treatment-naïve Individuals   

Adverse Events are the Main Cause of Treatment Failure in a Multicentre Trial in Naïve Patients, comparing Zidovudine/Lamivudine vs Stavudine/Didanosine, plus Efavirenz, Nevirapine or Indinavir/Ritonavir - 8/08/05

2-year Follow-Up of Combination Lopinavir/Ritonavir-Efavirenz - 8/08/05

Lack of Resistance to Tenofovir at Week 48 and Impact of Baseline Resistance Mutations on Treatment Response
- 8/08/05

High Rate of Virological Failure during Once-daily Therapy with Tenofovir + Didanosine 250mg + Efavirenz in Treatment-naive Patients
- 8/08/05

Efficacy and Safety of Once-Daily Abacavir/Lamivudine Fixed-dose Combination + Efavirenz
- 8/03/05

Immunologic Status at Time of Initial Evaluation: Consequences of Delayed HIV Diagnoses
- 8/01/05

Evaluation of 3 Once-daily Regimens as First-line HAART - 8/01/05

Outcome of Once-daily Regimen with Didanosine, Lamivudine and Efavirenz in Treatment-naïve Patients - 8/01/05

Superior 48-week Outcome for Tenofovir, Emtricitabine and Efavirenz Combination Regimen Compared to Fixed-dose Zidovudine/Lamivudine and Efavirenz in Treatment-naïve Patients
- 7/29/05

Treatment-naïve Patients Treated with Ritonavir-boosted Saquinavir Show No Significant Resistance to Protease Inhibitors - 7/29/05

Once-daily versus Twice-daily Lopinavir/Ritonavir in Treatment-naïve Patients: 96-week Results - 7/29/05

Immunologic Reconstitution through 6 Years in Antiretroviral-Naïve Patients Treated with Lopinavir/Ritonavir - 7/29/05

Therapy for Treatment-experienced Individuals   

Efficacy and Safety of a Once-daily Fixed-dose Combination of Abacavir/Lamivudine versus Abacavir Twice-daily and Lamivudine Once-daily as Separate Entities in Treatment-experienced Patients  -- 8/08/05

2-year Follow-Up of Combination Lopinavir/Ritonavir-Efavirenz - 8/08/05

Tipranavir/ritonavir 500 mg/200 mg BID Drives Week 24 viral load <400 copies/mL When Combined with Enfuvirtide in Protease Inhibitor-experienced HIV Patients
- 8/03/05

Once-Daily Salvage Regimens for Heavily Treatment-experienced HIV-Infected Patients in the Atazanavir Early Access Program in Spain - 8/03/05

Salvage Study of Experimental HIV Protease Inhibitor TMC-114 from Tibotec Yields Outstanding Results
- 8/01/05

Switching to Atazanavir from Other PI-based HAART Maintains Suppression, Results in Fewer Viral Rebounds and Improves Lipids and GI Tolerance: The SWAN Study
- 7/29/05

Lipids and Metabolic Complications   

Metabolic and Morphological Disturbances Reported at the 3rd IAS Conference - 8/22/05

Switching to Atazanavir from Other PI-based HAART Maintains Suppression, Results in Fewer Viral Rebounds and Improves Lipids and GI Tolerance: The SWAN Study
- 7/29/05


Prevention of HIV Infection   

Experimental NNRTI TMC 120 Appears Safe and Effective as Microbicide - 8/10/05



Pharmacokinetics and Drug Interactions   

Improvements in Lopinavir/Ritonavir Formulation - 8/10/05



Complications of Therapy / Adverse Events / Side Effects   

Adverse Events are the Main Cause of Treatment Failure in a Multicentre Trial in Naïve Patients, comparing Zidovudine/Lamivudine vs Stavudine/Didanosine, plus Efavirenz, Nevirapine or Indinavir/Ritonavir - 8/08/05

Salvage Therapy in Different Clinical Settings
- 8/05/05

Switching from Stavudine to Tenofovir Decreases Cardiovascular Risk - 8/05/05

Switch from PI- to Sustiva-based HAART Shows No Impact of Race on Efficacy and Nervous System Symptoms
- 8/03/05

TDF Affects Renal Function but Renal Failure Is Rare - 8/03/05

Frequency of Abacavir Hypersensitivity Reactions, Rechallenge Reactions, and HSR-attributable Outcomes Are Similar with the Use of Ziagen or Trizivir
- 8/01/05

Hyperbilirubinemia among Patients in the HIV Outpatient Study (HOPS) Receiving Atazanavir - 8/01/05

Tenofovir Affects Renal Function but Renal Failure Is Rare - 8/01/05

Safety of a Fosamprenavir/Ritonavir-containing Regimen Over 120 Weeks in HIV Positive Treatment-naïve Adults with or without hepatitis B and/or C Coinfection - 8/01/05

Safety of Abacavir + Lamivudine-based HAART in ART-naïve HIV Positive Subjects with and without Hepatitis B and/or Hepatitis C Coinfection - 8/01/05

Pattern of Hepatotoxicity on Different Antiretroviral Regimens in HIV Patients with or without Chronic Hepatitis B or Hepatitis C - 8/01/05

Liver Disease and Not HCV Coinfection May Be Predictive of a Higher Discontinuation of HAART - 8/01/05

Mother-to-Child Transmission (MTCT) / Prevention of MTCT / Pregnancy / Newborns
  

Routine Use of Combined Zidovudine and Nevirapine Regimen in MTCT-Plus Program - 8/03/05

Nevirapine Concentration in Cervico-vaginal and Oropharyngeal Secretions - 8/03/05

Timing of Maternal and Infant Nevirapine and the Risk of Mother-to-child Transmission of HIV - 8/03/05

6-month Immunological Response with HAART-containing Nevirapine in HIV Positive Women Post-exposure to Single-dose of Nevirapine for PMTCT - 8/03/05

Mother-to-Child Transmission of HIV: Where We Are and Where We Need to Go
- 8/01/05

Drug Resistance   


Lack of Resistance to Tenofovir at Week 48 and Impact of Baseline Resistance Mutations on Treatment Response - 8/08/05

Antiviral Activity and Safety of GW695634, a Next Generation NNRTI, in Patients with NNRTI-resistant HIV
- 8/08/05

HIV Drug Resistance Acquired through Superinfection
- 8/05/05

Incidence of K65R Mutation Is Not Increasing - 8/05/05


Developing Countries   


Effective Method for Transferring Skills and Knowledge to Developing Countries - 8/05/05

Clinical Mentoring Is Effective in Improving Skills for Health Care Providers in Developing Countries - 8/05/05





Epidemiology   


Contacts of the New York City “Superinfection” Case Identified - 9/09/05

Infection with Resistant Virus Is Not Associated with More Rapid Disease Progression
- 9/09/05

Immunologic Status at Time of Initial Evaluation: Consequences of Delayed HIV Diagnoses
- 8/01/05

New Therapeutic Approaches   


Treatment with Recombinant Growth Hormone Increases Total and Naïve CD4 Count Compared to HAART Alone - 7/27/05


Virological (Treatment) Failure   


High Rate of Virological Failure during Once-daily Therapy with Tenofovir + Didanosine 250mg + Efavirenz in Treatment-naive Patients - 8/08/05

Adverse Events are the Main Cause of Treatment Failure in a Multicentre Trial in Naïve Patients, comparing Zidovudine/Lamivudine vs Stavudine/Didanosine, plus Efavirenz, Nevirapine or Indinavir/Ritonavir
- 8/08/05

Quadruple Nucleoside/tide Regimen of Trizivir + Tenofovir Is Effective Following Early Virologic Failure on an Initial Regimen Containing a Thymidine Analog + Lamivudine + a PI or NNRTI - 8/08/05


Vaccines   

Vaccines with Naked DNA Appear Effective in Reducing the Viral Setpoint - 8/01/05

Treatment Strategies / Salvage Therapy and Treatment Failure   

Tipranavir/ritonavir Demonstrates Superior Response to Lopinavir/ritonavir, Amprenavir/ritonavir or Saquinavir/ritonavir in PI-experienced Patients - 8/08/05

Salvage Therapy in Different Clinical Settings
- 8/05/05

Tipranavir/ritonavir 500 mg/200 mg BID Drives Week 24 viral load <400 copies/mL When Combined with Enfuvirtide in Protease Inhibitor-experienced HIV Patients
- 8/03/05

Once-Daily Salvage Regimens for Heavily Treatment-experienced HIV-Infected Patients in the Atazanavir Early Access Program in Spain
- 8/03/05

Salvage Study of Experimental HIV Protease Inhibitor TMC-114 from Tibotec Yields Outstanding Results
- 8/01/05

Cost of HIV/AIDS Medical Care   

Lifetime Cost of HIV Care in the US in the Current Treatment Era - 8/01/05

Pathogenesis   

Host Factors and Viral Interactions - 8/05/05

HIV Pathogenesis
- 7/29/05

Dosing / Once-Daily Dosing (QD) / Fixed-dose Combinations   

High Rate of Virological Failure during Once-daily Therapy with Tenofovir + Didanosine 250mg + Efavirenz in Treatment-naive Patients - 8/08/05

Efficacy and Safety of a Once-daily Fixed-dose Combination of Abacavir/Lamivudine versus Abacavir Twice-daily and Lamivudine Once-daily as Separate Entities in Treatment-experienced Patients 
-- 8/08/05

Patient Satisfaction with Abacavir-Lamivudine Fixed-dose Combination (FDC) Tablet Once daily (QD) Compared with Abacavirand Lamivudine Twice-daily - 8/08/05

Once-daily HAART More Effective than Twice-daily Regimen
- 8/05/05

Efficacy and Safety of Once-Daily Abacavir/Lamivudine Fixed-dose Combination + Efavirenz
- 8/03/05

Once-Daily Salvage Regimens for Heavily Treatment-experienced HIV-Infected Patients in the Atazanavir Early Access Program in Spain - 8/03/05

Evaluation of 3 Once-daily Regimens as First-line HAART
- 8/01/05

Outcome of Once-daily Regimen with Didanosine, Lamivudine and Efavirenz in Treatment-naïve Patients - 8/01/05


Viral Diversity   

Molecular Epidemiology and Transmission
- 8/03/05

Diversity of HIV: Viral Recombinants Are Increasing - 8/03/05


Sexual Transmission of HIV   

Molecular Epidemiology and Transmission - 8/03/05

Update on “Patient Zero” 
- 7/29/05

High Risk for Transmission of Drug-resistant HIV among HIV Patients in Routine Clinical Care
- 7/27/05

Patient Zero: the Connecticut Source of the Multi-drug Resistant, Rapidly Progressing HIV-1 Strain Found in New York City
- 7/27/05






 


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