HIV
and Hepatitis.com Coverage of the 14th
Annual Conference on Retroviruses and Opportunistic Infections (14th CROI) February
25 - 28, 2007, Los Angeles, CA
CD4+
T Cell Recovery and Reconstitution of Gut Tissue In AIDS Patients Treated with
Viramune plus Trizivir
Gut-associated
lymphoid tissue (GALT) harbors the majority of CD4+
T cells and is rapidly depleted in early HIV
infection. Prior study results suggest that reconstitution of CD4+ T cells
in HAART-treated individuals
is less complete in GALT than in peripheral blood (PB).
Most
studies have evaluated GALT by flow cytometry, which provides relative estimates
of CD4+ T cells. In the present study, researchers hypothesized that reconstitution
of CD4+ T cells in GALT may have been underestimated by this method and that absolute
numbers of CD4+ T cells reconstituted in GALT exceed those in PB.
Based
on their assessment of the biopsies and other data, the researchers conclude,
"Treatment with Viramune/Trizivir in advanced HIV-1 infection results in
substantial recovery of CD4+ T cells and reconstitution of tissue architecture
in GALT. Increases in CD4+ T cells are significantly larger in GALT than PB, particularly
during the first 24 weeks of therapy." Link
to full study abstract.
University
of Colorado at Denver and Health Sciences Center, Denver, CO, Weber State University,
Ogden, UT, Denver Department of Public Health, Therapeutic Concepts, PA, Houston,
TX, Pharmaceutical Product Development, Inc., Menlo Park, CA, AnorMED, Inc, Langley,
BC.
03/09/07
Reference E
Connick, D Shenefelt, J Folkvord, and others. SubstantialCD4+ T Cell Recovery
and Reconstitution of Tissue Architecture in Gut Associated Lymphoid Tissue (GALT)
in Advanced HIV-1 Infection Following Initiation of HAART. 14th Conference on
Retroviruses and Opportunistic Infections. Los Angeles. February 25-28, 2007.
Abstract 28 (oral).
