HIV and Hepatitis.com Coverage of the
4
th IAS Conference on HIV Pathogenesis, Treatment and Prevenion (IAS 2007)
July 22-25, 2007, Sydney, Australia

Library of Slides and Posters

    Therapy for Treatment-naïve Patients

    Therapy for Treatment-experienced Patients

  Lipodystrophy and Metabolic Changes

  HIV-related Adverse Events

  Pharmacokinetic Interactions



Therapy for Treatment-naïve Patients

A Randomized Comparative Trial of First-line Antiretroviral Therapy with Regimens Containing Either Nevirapine, or Efavirenz, Together with Stavudine and Lamivudine. Three-Year Extended Follow-Up of the 2NN Study.
F Wit and others.

Predicting Response to Therapy for HIV-1 Infection in ART-naïve Adults Starting HAART Regimens by Using the Week 8 Time-point
L Yau and others. Copyright GlaxoSmithKline. Used with permission, 2007.

An Open-Label, Two-Period, Crossover, PK Study of Abacavir (ABC) and Its Intracellular Anabolite Carbovir Triphosphate (CBV-TP) Following 600mg Once-Daily and 300mg Twice-Daily Administration of Abacavir in HIV-Infected Subjects

G Moyle and others. Copyright GlaxoSmithKline. Used with permission, 2007.

Once-Daily Ritonavir (100mg) Boosting of Fosamprenavir (FPV/r) or Atazanavir (ATZ/r) with Tenofovir (TDF)/Emtricitabine (FTC) in Antiretroviral-Naive HIV-Infected Patients: 48-week Safety/Efficacy Results from COL103952 (ALERT)
K Smith and others. Copyright GlaxoSmithKline. Used with permission, 2007.

Long-Term Efficacy and Safety of Fosamprenavir (FPV) 1400 mg Once-Daily (QD) Boosted by Ritonavir (RTV) 100 mg QD in Previously Antiretroviral-Naïve HIV/AIDS Patients: Phase I of BOLD100 (COL109766)
G Blick and others. Copyright GlaxoSmithKline. Used with permission, 2007.

Virologic Response and Tolerability by Sex and Race in Subjects Receiving Fosamprenavir/ritonavir (FPV/r) BID and Lopinavir/ritonavir (LPV/r) BID, each in Combination with Abacavir/Lamivudine QD (the KLEAN Study)
E DeJesus and others. Copyright GlaxoSmithKline. Used with permission, 2007.

Once-Daily Abacavir/Lamivudine (ABC/3TC) and Boosted Atazanavir (ATV/r): 48-Week Analysis from COL102060 (SHARE)
R Elion and others. Copyright GlaxoSmithKline. Used with permission, 2007.

LPV/r-based 2-drug HAART vs LPV/r-based 3-drug HAART: Comparable Virological Efficacy and Tolerability in HIV-1-infected Naïve Subjects (Kalead-1 study) 48-week Results
M Pinola, G Carosi, G Di Perri, and others

Single-agent Therapy with Lopinavir/ritonavir Suppresses Plasma HIV-1 Viral Replication in HIV-naïve Subjects: IMANI-2 48-week Results
J C Gathe Jr, R F Yeh, C Mayberry, and others

Saquinavir/r (SQV/r) BID vs lopinavir/r (LPV/r) BID plus emtricitabine/tenofovir (FTC/TDF) QD as initial therapy in HIV-1 infected patients: the Gemini Study.
F Raffi, D Ward, K Ruxrungtham, and others



Therapy for Treatment-experienced Patients

Week 8 response predicts Week 48 virological responses to tipranavir/r in the RESIST studies
J Ernst and others.

Soluble Immune Markers in Individuals Treated for 6 Years with a Lopinavir/ritonavir (LPV/./r)-based Antiretroviral (ARV) Regimen
A Landay, M King, J Tschampa, and others


Lipodystrophy and Metabolic Changes

Nevirapine Increases High Density Lipoprotein-cholesterol by Stimulation of Apolipoprotein A-I Synthesis
R Sankatsing and others.

Determination of Body Composition Changes by Total Body Dual-Energy X-ray Absorptiometry after 48 Weeks of Treatment with Once-Daily Fosamprenavir (FPV) Boosted with Two Different Doses of Ritonavir(r) plus Abacavir(ABC)/Lamivudine(3TC): COL100758

D Wohl and others. Copyright GlaxoSmithKline. Used with permission, 2007.

Once-Daily Abacavir/Lamivudine (ABC/3TC) and Boosted Atazanavir (ATV/r): 48-Week Analysis from COL102060 (SHARE)
R Elion and others. Copyright GlaxoSmithKline. Used with permission, 2007.

One-year Fat Tissue Distribution Changes in Antiretroviral Naïve HIV-infected Patients Treated with Lopinavir/ritonavir (LPV/r) Monotherapy versus LPV/r with Zidovudine/lamivudine (AZT/3TC) in the MONARK Trial
J F Delfraissy, P Flandre, P Van Ngo Van, and others

Changes in Lipid Parameters During Treatment with Lopinavir/ritonavir (LPV/r) Plus Zidovudine/lamivudine (ZDV/3TC) Induction Followed by Maintenance on LPV/r Monotherapy Compared to Efavirenz (EFV) + ZDV/3TC through 96 Weeks
B da Silva, P Domingo, V Joly V, and others

Eztimbe Combined with Low Dose Statin Effectively Lowers LDL in Protease Inhibitor Treated Patients
O Klibanov, JGaughan, E Tedaldi, and others

Evaluation of the impact of highly active antiretroviral therapy (HAART) on lipid profiles – data from the 24-week interim analysis of the Gemini Study: saquinavir/r (SQV/r) BID vs lopinavir/r (LPV/r) BID plus emtricitabine/tenofovir (FTC/TDF) QD in ARV-naïve HIV-1-infected patients.
S Walmsley, U Bredeek, A Avihingsanon, and others


HIV-related Adverse Events

No Change in Glucose Tolerance with Lopinavir/ritonavir (LPV/r) + ZDV/3TC Induction Followed by LPV/r Monotherapy through 96 Weeks
B da Silva, M King, M Dehaan, and others




Pharmacokinetic Interactions

Efficacy and Safety of Fosamprenavir/ritonavir (FPV/r) BID or Lopinavir/ritonavir (LPV/r) BID in Antiretroviral Treatment-Naïve Subjects Co-Infected with Hepatitis B (HBV) or C (HCV) and HIV (the KLEAN Study)
D Norris and others. Copyright GlaxoSmithKline. Used with permission, 2007.