The Doctor Is In Q and A: Hepatitis B and an HBV Surface Antigen Positive (HBsAg+) Test Result

”I have been infected with the hepatitis B virus for more 30 years with no symptoms at all. The blood test results consistently present as follows:

HBs Ag positive
HBV core Ab positive
HBeAg negative
HBsAb Negative
HBV DNA Negative
Liver functions normal

”I have no problems and have never used treatment. My doctor told me that I don't need any treatment because he believes that I am non-infectious and not at risk to myself or to others, so I don't need to have a blood test regularly. But I have just wondered lately if need to take a blood test regularly? How often, if needed? Is there any possible my HBV PCR can become positive and I will become infectious?  What symptoms would I notice if my HBV PCR test result became positive? And what should I do then?  My husband and my son are HBV negative.” –JP

Answer by Mack Mitchell, MD
As long as the HBsAg is positive, then there is a potential for infection.  It is probably very low if the HBV DNA is undetectable.  However, the level of sensitivity of this test is only 100 copies/ml for the best tests and 400 copies/ml for others, so it is possible to have small amounts of virus remaining. 

For that reason all family members and intimate contacts should be vaccinated.  It is unlikely, although possible, that reactivation of the infection can occur in the future.  This usually happens if your immune system is suppressed for any reason, either because of other illnesses or because of medications used to treat other illnesses.  This has caused problems in some people.  For that reason, it is best to check HBV DNA and ALT at least once or twice each year.

Link to today’s The Doctor Is In Q and A






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