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HIV Coreceptor Tropism Affects Treatment Outcomes

HIV strains that use the CXCR4 co-receptor are associated with higher risk of virological failure on antiretroviral therapy than those using CCR5, according to a recent Spanish study. alt

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Elevated CD8 Cell Count Predicts HIV Treatment Failure

High or rising CD8 T-cell counts after starting combination antiretroviral therapy appears to predict virological treatment failure. alt

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CROI: Do Black Patients Respond Less Well to Antiretroviral Therapy?

African-Americans had a 40% greater likelihood of virological failure on antiretroviral therapy even after controlling for known risk factors, according to a meta-analysis of ACTG trials presented at CROI 2011.

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Early CD4 Counts May Predict Immune Recovery

A higher CD4 cell count when first diagnosed with HIV infection predicts better immunological recovery after starting antiretroviral therapy, according to an analysis of a U.S. military cohort. alt

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Can Genetic Testing Predict Antiretroviral Drug Side Effects?

Genetic variations can help identify which HIV patients are most likely to prematurely stop certain antiretroviral drugs due to adverse events, according to study findings reported in the January 15, 2011 Journal of Infectious Diseases. Researchers looking at a mostly European population found genetic markers significantly associated with early discontinuation of efavirenz (Sustiva)andatazanavir (Reyataz).

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