CROI 2013: MK-1439, a Novel HIV NNRTI, Shows Promise in Early Clinical Trials


A next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), MK-1439, demonstrated robust antiretroviral activity and good tolerability as monotherapy in a small clinical study, researchers reported yesterday at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta.

NNRTIs are a generally well-tolerated and are well-suited for first-line HIV treatment, but as a class these drugs are susceptible to resistance. Pre-clinical studies showed that MK-1439 has enhanced activity against HIV strains with certain other common NNRTI resistance mutations (including K103N and Y181C). Unlike the widely used NNRTI efavirenz (Sustiva), it appears to have low potential for central nervous system (CNS) toxicity.

Matt Anderson from Merck and colleagues evaluated MK-1439 in a double-blind, placebo-controlled trial at a single site in Berlin. The researchers looked at drug safety, tolerability, antiviral activity, pharmacokinetics, and viral resistance during administration of multiple doses.

This study was the first to test multiple doses of MK-1439 in HIV positive people. Prior research showed acceptable safety and pharmacokinetics in HIV negative volunteers given single doses up to 1200 mg(also reported at CROI, poster 527).

This analysis included 18 previously untreated people with HIV. Although both men and women were eligible, only men enrolled in the trial. Ages ranged from 23 to 45 years. At study entry they had at CD4 T-cell counts of at least 200 cells/mm3, and biochemistry and blood lab results were normal. People with hepatitis B or C coinfection were excluded.

Participants were evenly randomized to receive 25 mg or 200 mg once-daily MK-1439 or placebo as monotherapy for 7 days. After completion of dosing, participants were started on standard combination antiretroviral therapy for 10 more days, so that residual MK-1439 would not promote development of resistance in the absence of other antiretrovirals.


"MK-1439 was generally well tolerated with no clinically significant trends or signals apparent in vital sign measurements, laboratory findings, or ECGs," the researchers concluded. "Similarly robust antiviral activity against HIV-1 was observed with 25 and 200 mg QD [once-daily] doses."

Anderson said that a Phase 2b clinical trial is currently enrolling to compare MK-1439 vs efavirenz, both with tenofovir/emtricitabine (the drugs in Truvada). More details are available at

SEE ALSO: MK-1439 -- A Novel NNRTI For HIV Treatment [VIDEO]



M Anderson, J Gilmarti, M Robberechts, et al. Safety and Antiviral Activity of MK-1439, a Novel NNRTI, in Treatment-naive HIV+ Patients. 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, March 3-6, 2013. Abstract 100.

M Anderson, J Gilmarti1, M Robberechts, et al. Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of MK-1439, a Novel HIV NNRTI, in Healthy Subjects. 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, March 3-6, 2013. Abstract 527.