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Gilead and Tibotec To Develop New Combo Pill

Gilead Sciences and Tibotec Pharmaceuticals announced a collaboration to develop a fixed-dose combination pill containing the protease inhibitor darunavir (Prezista) plus the novel boosting agent cobicistat.

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Study Sheds Light on Residual Viral Load

Residual low-level HIV plasma viremia correlates with size of the CD4 T-cell reservoir, but not immune activation markers. alt

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New HRSA Guide for HIV/AIDS Clinical Care

An updated version of the Health Resources and Services Administration (HRSA) Guide for HIV/AIDS Clinical Care is now available free online.

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HIV Coreceptor Tropism Affects Treatment Outcomes

HIV strains that use the CXCR4 co-receptor are associated with higher risk of virological failure on antiretroviral therapy than those using CCR5, according to a recent Spanish study. alt

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Elevated CD8 Cell Count Predicts HIV Treatment Failure

High or rising CD8 T-cell counts after starting combination antiretroviral therapy appears to predict virological treatment failure. alt

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Tobira Starts Phase 2b Cenicriviroc Trial

Tobira Therapeutics recently opened a middle-phase trial of its dual CCR5/CCR2 inhibitor cenicriviroc (TBR-652).

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Older HIV+ People May Benefit from Earlier ART

Starting antiretroviral treatment at higher CD4 T-cell counts predicted better long-term immune recovery in a large U.S. cohort, while age over 50 years and hepatitis B or C coinfection were linked to smaller CD4 cell gains.

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