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CROI 2015: Weekends Off Treatment Works Well for Some Young People with HIV [VIDEO]

Taking breaks from antiretroviral therapy on the weekend did not lead to viral rebound or other problems for adolescents and young adults who had prolonged viral suppression on efavirenz-based regimens, according to a presentation at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) this week in Seattle.

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CROI 2015: PrEP Use Rising in San Francisco, but Scale-Up Could Cut New Infections

Use of Truvada (tenofovir/emtricitabine) pre-exposure prophylaxis, better known as PrEP, is increasing in San Francisco, but it is still only reaching about one-third of people who could benefit, and wider use could reduce new HIV infections by 70%, according to a report at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) this week in Seattle.

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HIV Transmission Happens at All Stages of Care Cascade

People living with HIV who are not yet aware they are infected, and those who have been diagnosed but are not yet receiving care and treatment, may account for more than 90% of HIV transmission, according to a Centers for Disease Control and Prevention (CDC) study published in the February 23 edition of JAMA Internal Medicine. Moving people through the care cascade could therefore both benefit individuals with HIV and prevent new infections.

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CROI 2015: PrEP Stops 86% of HIV Infections in PROUD Study

A study of pre-exposure prophylaxis (PrEP), the English PROUD study, demonstrated the highest effectiveness yet seen for this method of HIV prevention, the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle heard today. The effectiveness was 86%; for every 20 infections that might have occurred in participants, 17 were stopped by PrEP. 

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CROI 2015: European PrEP Studies Find High and Equivalent HIV Protection

The UK PROUD study of once-daily Truvada (tenofovir/emtricitabine) pre-exposure prophylaxis (PrEP), and the French Ipergay study of "on-demand" PrEP taken before and after sex, both saw an 86% reduction in new HIV infections, researchers reported at the at the 2015 Conference on Retroviruses and Opportunistic Infections(CROI) this week in Seattle.

PrEP Stops 86% of HIV Infections in PROUD Study

On-Demand PrEP Prevents 86% of HIV Infections in Ipergay

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CROI 2015: On-Demand PrEP Prevents 86% of HIV Infections in Ipergay

A French and Canadian study of pre-exposure prophylaxis (PrEP) presented today at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle found that the HIV infection rate for participants taking an intermittent PrEP regimen was 86% lower than for people taking an inactive placebo. Extraordinarily, this is exactly the same level of effectiveness that was demonstrated in the English PROUD study, whose outcomes were presented 15 minutes before Ipergay. Ipergay is a very different study than PROUD and it is encouraging that 2 different ways of taking PrEP have both proved effective in gay men, at least in a western European context.

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Gay Men Better at Predicting When They Won't Have Sex than When They Will

A study in which a group of HIV negative gay and bisexual men from New York City were asked to predict each day whether they would have sex the following day, and then compared their prediction with what actually happened, found that men generally overestimated the likelihood they would have sex. This study, published in the April 1 Journal of Acquired Immune Deficiency Syndromes, suggests possible pre-exposure prophylaxis (PrEP) dosing strategies.

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