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IDSA Issues New Guidelines for Vaccination of Immune-compromised People

The Infectious Diseases Society of America (IDSA) this month released new recommendations for vaccinations for people with HIV and other immune-compromising conditions. The guidelines were published in the December 4, 2013, advance edition of Clinical Infectious Diseases.

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Conditioning with Cytoxan Increases Protected Cells in HIV Gene Therapy Trial

Administering cyclophosphamide (Cytoxan), a chemotherapy drug toxic to certain immune cells, prior to zinc-finger gene therapy appears to make room for increased proliferation of altered CD4 T-cells lacking the CCR5 co-receptor, researchers reported at the 6th International Workshop on HIV Persistence during Therapy last week in Miami.

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HIV Re-emerges in Boston Bone Marrow Transplant Patients

Two bone marrow stem cell recipients who had undetectable HIV according to the most sensitive tests for months after an experimental antiretroviral therapy (ART) interruption have experienced viral rebound and had to restart treatment, frustrating hopes for a functional cure, according to a report at the 6th International Workshop on HIV Persistence during Therapy last week in Miami.

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Antiretroviral Treatment Has Saved Nearly 3 Million Life-years in South Africa

Widespread use of effective antiretroviral therapy (ART) has led to "massive benefits" in hard-hit South Africa, saving an estimated 2.8 million life-years by 2012, and potentially up to 22 million years over the lifetime of treated individuals, according to a modeling study described in the December 3, 2013, advance edition of the Journal of Infectious Diseases.

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World AIDS Day: More Funding for HIV Cure, Global Fund, No One on ADAP Wait List

Acknowledging World AIDS Day on December 1, President Obama announced that the National Institutes of Health (NIH) would reallocate $100 million over the next 3 years towards HIV cure research and donate up to $5 billion to the Global Fund to Fight AIDS, Tuberculosis and Malaria. In other funding news, NASTAD announced last week that there are currently no people with HIV on AIDS Drug Assistance Program (ADAP) waiting lists.

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HIV/AIDS Community Mourns Passing of Nelson Mandela

Numerous HIV/AIDS activists and organizations have joined the worldwide chorus of acclaim for former South African president Nelson Mandela, who in his later years was credited with strengthening that country's response to AIDS, especially after his son died of the disease.

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New HIV Strain May Lead to Faster Disease Progression

A newly identified natural recombinant form of HIV, dubbed A3/02, was associated with nearly a 3-fold higher risk of progression to AIDS and AIDS-related death -- as well as a shorter time from seroconversion to AIDS or death --compared with 2 more common types found in West Africa, researchers reported in the August 9 advance edition of the Journal of Infectious Diseases.

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