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CROI 2015: Inflammation and Gut Damage Persist in People with HIV Despite Early ART

Inflammatory changes and damage to the gut begin very soon after initial HIV infection, and may not return to normal even when people start antiretroviral therapy (ART) very early, researchers reported at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle. Biomarkers of inflammation, coagulation and fibrosis increased early on, and while they generally decreased after starting ART, they did not fall to levels seen in HIV-negative people.

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CROI 2015: Tenofovir, Atazanavir & Lopinavir Associated with Raised Risk of Chronic Kidney Disease

Three antiretroviral drugs are associated with a slowly increasing rate of chronic kidney disease over time, researchers reported at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle. Although the risk of developing chronic kidney disease was low for people with normal kidney function -- with fewer than 1% of patients in the large D:A:D cohort developing it -- the use of any of these drugs was associated with 2 to 3 times higher risk of kidney disease developing over the course of 5 years on the drug.

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CROI 2015: Antiretroviral Therapy -- Past, Present and Future [VIDEO]

Antiretroviral therapy (ART) has undergone a remarkable evolution from AZT monotherapy in the late 1980s, to effective combination therapy in the mid-1990s, to today's well-tolerated single-tablet regimens. But questions about the optimal time to start treatment remain unanswered and getting ART to everyone who needs it is still a challenge, according to a presentation by David Cooper at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.

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CROI 2015: PEPFAR Abstinence and Faithfulness Funding Had No Impact on Sexual Behavior in Africa

Nearly $1.3 billion spent on U.S.-funded programs to promote abstinence and faithfulness had no significant impact on sexual behavior in 14 countries in sub-Saharan Africa, an analysis of sexual behavior data has shown. The preliminary findings were presented by Nathan Lo of Stanford University School of Medicine at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.

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March 10 Is National Women and Girls HIV/AIDS Awareness Day

Tuesday, March 10, is National Women and Girls HIV/AIDS Awareness Day (NWGHAAD), an annual opportunity to call attention to the impact of HIV and AIDS on women and girls worldwide.

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CROI 2015: No HIV Transmissions from HIV+ Partners Seen in Australian Gay Couples Study

An Australia-based study of gay male couples of opposite HIV status (serodiscordant couples) has so far seen no transmissions from the HIV-positive partner within the couple in a 2-year interim analysis, researchers reported at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.

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CROI 2015: Statins May Reduce Risk of Heart Disease in People with HIV

Evidence is mounting that statin therapy can prevent the progression of coronary atherosclerosis (hardening and narrowing of the arteries supplying the heart) in people living with HIV, according to the results of 2 randomized clinical trials reported last week at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.

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