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HIV / AIDS

Atlanta Principles Call for Stepped Up HIV Prevention, Focus on Vulnerable Groups

ACT UP, the Treatment Action Group (TAG), and local advocates this week launched the Atlanta Principles, calling on the Centers for Disease Control and Prevention (CDC) to increase HIV prevention efforts -- including antiretroviral treatment-as-prevention and pre- and post-exposure prophylaxis -- to lower HIV incidence rates that have remained stable overall for several years and actually risen for heavily affected groups such as young black gay men and transgender women.

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Clinical Trial of Once-Daily Raltegravir Now Underway

Merck announced this week that treatment-naive participants are now being enrolled in the Phase 3 ONCEMRK trial, which is evaluating the efficacy and safety of a ne formulation of the HIV integrase inhibitor raltegravir (Isentress) taken once rather than twice daily.

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AAHIVM, AGS, and ACRIA Release Updated Recommendations for Older Patients with HIV

The American Academy of HIV Medicine (AAHIVM), ACRIA, and the American Geriatrics Society (AGS) this week announced a major update to its 2011 report,  Recommended Treatment Strategies for Clinicians Managing Older Patients with HIV, available online at www.HIV-Age.org. Revised topics include assessing functional capacity, smoking cessation, and management of diabetes, COPD, osteoporosis, and hypertension.

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People with HIV Are at Higher Risk for Cancers Linked to Smoking, Viruses

People with HIV appeared to have a higher overall rate of cancer in a large Danish study, but the difference was only significant for malignancies caused by smoking or other viruses, including lung cancer, anal cancer, and liver cancer. A related U.S. study found the rate of prostate cancer was actually lower among HIV positive men.

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New Studies Offer More Insight on HIV Sexual Transmission and Prevention

A new estimate puts the likelihood of HIV transmission via receptive anal sex at 138 per 10,000 acts, but looking at probabilities over a longer period provides a better understanding of risk than per-act probabilities, according to a pair of studies in the May 6 advance online edition of AIDS. Mathematical models showed that combining prevention methods -- especially those that include antiretroviral treatment-as-prevention or PrEP -- can greatly reduce the risk of transmission.

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June 5 is National HIV/AIDS Long-Term Survivors Awareness Day

The first National HIV/AIDS Long-Term Survivor Awareness Day (NHALTSAD) will take place this week on June 5. The day is one that has historical significance in San Francisco, but also globally, because it was the same day in 1981 that the U.S. Centers for Disease Control (CDC) reported the first cases of a new and devastating disease we now know as AIDS.

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Kidney Drug Sevelamer May Reduce Gut Leakage During Acute HIV Infection

The phosphate-binding agent sevelamer can bind to bacterial toxins and reduce excessive immune activation in macaque monkeys with a simian virus similar to HIV, according to a report in the June 2 Journal of Clinical Investigation. A related study, however, failed to see a reduction in inflammation biomarkers in people with untreated HIV disease.

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