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Truvada PrEP Did Not Cause Major Kidney Problems in HIV Prevention Trial

Gay men who used Truvada (tenofovir/emtricitabine) for HIV pre-exposure prophylaxis (PrEP) were unlikely to develop impaired kidney function in the iPrEx study, according to a report in the February 4 advance edition of AIDS. Creatinine clearance decreased slightly on average among Truvada recipients, but returned to normal after stopping PrEP.

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Circumcision Still Effective for HIV Prevention After 6 Years

Voluntary adult male circumcision continued to be associated with about a 60% reduction in the risk of HIV infection after 6 years of follow-up, according to a study in Kenya described in the November 28, 2013, issue of AIDS.

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HIV Regimens with Fewer Pills Promote Adherence and Viral Suppression

Antiretroviral regimens that contain fewer pills are associated with improvement in treatment adherence and higher likelihood of achieving undetectable viral load, according to a meta-analysis published in the January 22, 2014, advance edition of Clinical Infectious Diseases. Once-daily dosing however, had only a modest effect on adherence and did not significant impact viral suppression.

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Updated Guidelines for Antiretroviral Treatment of Children with HIV

The Department of Health and Human Services this week updated its Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. Changes to the children's guidelines include specific drug recommendations and information about a possible cure of an HIV-infected infant following very early treatment.

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New Website Offers Resources on HIV and Aging

The American Academy of HIV Medicine (AAHIVM), the American Geriatrics Society (AGS), and ACRIA this week launched a new website, HIV-Age.org, that offers information and resources for clinicians who provide care for older patients with HIV.

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Inflammation Markers Linked to Disease Progression and Death in People with HIV

Levels of several inflammatory biomarkers were associated with a higher risk of developing AIDS-defining and non-AIDS events among participants in a large clinical trial, researchers reported in the February 1, 2014 Journal of Acquired Immune Deficiency Syndromes. A related study also saw a link between inflammatory markers and mortality in a group of HIV positive adults with alcohol problems.

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Doctors & Advocates Demand Better Health Coverage for HIV & Hepatitis

Coverage of preferred drugs in treatment guidelines, access to expert providers, lower co-pays, and clarity about patient assistance programs are among the steps HIV medical providers and patient advocates recommend to ensure that people with HIV and hepatitis C receive adequate care and treatment under the Affordable Care Act, according to separate statements released this week.alt