FDA Approves Diarrhea Drug Crofelemer for People with HIV/AIDS

On December 31, the U.S. Food and Drug Administration (FDA) approved crofelemer (brand name Fulyzaq) for treatment of diarrhea in people with HIV/AIDS on antiretroviral therapy (ART) -- the first approved medication for this indication.


New HIV Infections Down for U.S. Black Women, Still Rising for Young Gay Men

HIV incidence continues to climb for young men who have sex with men (MSM) -- the group with the highest incidence -- showing a 22% increase between 2008 and 2010, according to new data from the Centers for Disease Control and Prevention (CDC). The rate fell by 21% among African-American women, however, representing the first-ever significant decline.


AIDS Activist Spencer Cox Dies of AIDS-related Causes

Spencer Cox, a leading AIDS activist who played a key role in the development of effective antiretroviral therapy, died of AIDS-related causes at Columbia Presbyterian Hospital in New York City last Tuesday, December 18. He was 44.


WHO, UNAIDS, NSWP Release Guidelines to Reduce Sex Workers' HIV Burden

A report released by the World Health Organization (WHO) and collaborating organizations earlier this month proposes guidelines for public health and legal systems to reduce the vulnerability of sex workers to HIV and other sexually transmitted infections (STIs). Sex worker advocates generally favored the recommendations, but raised concerns about presumptive antibiotic treatment.


HIV+ Smokers on Antiretroviral Treatment Lose More Years to Smoking than to Virus

Researchers in Denmark, where antiretroviral therapy (ART) is free and widely used, found that HIVpositive smokers tripled their risk of death, and mortality associated with tobacco use was greater for people with HIV than for the general population, according to a study published in the December 18, 2012, advance edition of Clinical Infectious Diseases.


Top 12 HIV and Hepatitis Stories of 2012

In our last issue for 2012, reviews some the year's major HIV and viral hepatitis news highlights. On the HIV front, U.S. treatment guidelines recommended antiretroviral therapy (ART) for all HIV positive people, Truvada was approved for pre-exposure prophylaxis (PrEP), and HIV criminalization and cure research were highlighted at the International AIDS Conference in July. Promising findings were reported for several interferon-free oral regimens for hepatitis C, experimental tuberculosis (TB) drugs showed good results, and the Affordable Care Act remained on track.alt


Researchers Show How HIV Enters Dendritic Cells and Spreads to CD4 T-Cells

A receptor known as Siglec-1 on the surface of dendritic cells latches on to HIV's outer membrane and enables the virus to enter these cells, which carry it to lymphoid organs where it can infect neighboring CD4 T-cells, according to research published in the December 18, 2012, edition of PLoS Biology.