4. HIV Cure Setbacks: Mississippi Baby and Bone Marrow Transplants

The quest for an HIV cure saw some setbacks in 2014, with further news about 2 stem cell transplant patients in Boston who experienced HIV rebound several months after interrupting antiretroviral therapy (ART). This was followed in July by an announcement that HIV was detected in a child in Mississippi who had maintained undetectable viral load for more than 2 years off treatment.


5. HIV Treatment as Prevention: No Infections in PARTNER Study

Pre-exposure prophylaxis (PrEP) for HIV negative people was the biggest topic in HIV prevention in 2014, but use of antiretroviral therapy by HIV positive people to prevent onward transmission of the virus -- dubbed treatment as prevention or TasP -- also received further support.


8. HIV Treatment Cascade: Majority in U.S. Have Uncontrolled Virus

On the HIV treatment cascade front, the Centers for Disease Control and Prevention reported in December that less than one-third of people living with HIV in the U.S. have an undetectable viral load, with most of the drop-off attributable to people who had been diagnosed with HIV but did not go on to receive further care


6. HIV Drugs: Few New Approvals, but Pipeline Looks Promising

HIV drug development news in 2014 included approval of a new single-tablet regimen and 2 more components of antiretroviral therapy (ART). Promising candidates in the pipeline include a better-tolerated version of tenofovir, a NNRTI with fewer neuropsychiatric side effects, and potential long-acting injectables that may be useful for treatment or pre-exposure prophylaxis.


People with HIV May Experience Low- and High-Frequency Hearing Loss

People living with HIV were found to have impairment in both low-frequency and high-frequency hearing, but no association was seen with disease variables such as CD4 T-cell count or type of antiretroviral treatment, according to a recently published study.


7. AIDS Long-Term Survivors and Aging with HIV

Long-term survivors of the AIDS epidemic continued to make news in 2014, with the first-ever National HIV/AIDS Long-Term Survivors Awareness Day. There was more confirmation that people who start HIV treatment early may have a life expectancy matching that of uninfected individuals, but older people with HIV face health issues including cardiovascular disease and frailty.


CCR5-Delta-32 Stem Cell Transplants Unsuccessful in 6 Patients -- Berlin Patient Remains the Sole HIV Cure

Bone marrow transplants from donors with a naturally occurring mutation that protects immune cells from HIV failed to cure 6 additional HIV positive blood cancer patients, leaving "Berlin Patient" Timothy Ray Brown as the only person to show no signs of HIV infection several years after receiving this type of transplant, Brown's doctor Gero Hütter reported in the December 18 New England Journal of Medicine. Brown recently published his own story of being the only man known to be cured of HIV.alt