Coinfection

CROI 2017: Higher than Expected HCV Prevalence Among HIV- Gay Men in Amsterdam PrEP Program

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An unexpectedly high number of HIV-negative gay and bisexual men taking pre-exposure prophylaxis (PrEP) in Amsterdam were found to have hepatitis C virus (HCV) infection, suggesting HCV is being transmitted sexually between men with and without HIV, according to a presentation last month at the Conference on Retroviruses and Opportunistic Infections in Seattle.

Starting in the early 2000s researchers in the U.K. and elsewhere in Europe have reported clusters of apparently sexually transmitted acute HCV infection among HIV-positive men who have sex with men (MSM). Similar outbreaks followed in Australia and the U.S.

Several risk factors have been implicated -- including condomless anal sex, fisting, use of sex toys, other sexually transmitted infections (STIs), and non-injection drug use -- but these have not been consistent across studies. Experts have traditionally assumed that HCV is transmitted through sexual activities that involve blood, but the virus has also been detected in semen, rectal secretions, and feces.

To date sexually transmitted HCV has mostly been seen among HIV-positive MSM, with much lower rates (generally around 1% or less) among HIV-negative men, comparable to that of the general population. But cases of apparent sexually acquired HCV have been reported among HIV-negative gay men as well -- includingin the Kaiser Permanente San Francisco PrEP program and the U.K. PROUD and French Ipergay PrEP studies -- and there is some evidence these may be increasing.

Elske Hoornenborg and colleagues looked at HCV prevalence among HIV-negative gay and bi men at high risk for acquiring HIV who enrolled in the Amsterdam Pre-Exposure Prophylaxis Project (AMPrEP) run by the Amsterdam Public Health Service.

Men seeking PrEP were tested for HCV antibodies (indicating that someone has ever been infected, including those who spontaneously cleared the virus or were successfully treated) and HCV RNA (indicating active viral replication).

Among those who tested positive for HIV RNA, part of the HCV NS5B gene was sequenced and used to construct phylogenetic trees. These show how closely related viruses from different people are and can shed light on transmission networks. The researchers compared HCV sequences from 375 HIV-negative AMPrEP participants and 182 HIV-positive gay and bi men with acute HCV infection in the Dutch MOSAIC cohort.

Results

"HCV prevalence among HIV-negative MSM who started PrEP was higher than expected (based on the literature)," the researchers concluded. "HIV-negative MSM with HCV infection were infected with HCV strains already circulating among HIV-positive MSM, which suggests overlap between HIV-positive and HIV-negative MSM."

Based on these findings, they recommended that routine HCV testing should be offered to gay and bi men at high risk for HIV, especially those enrolling in PrEP programs.

Presenting similar data at the recent HIV in Europe (HepHIV2017) meeting in Malta, Maria Prins from the Amsterdam team suggested that diagnosing and treating hepatitis C early in high-risk gay and bi men could potentially bring about a rapid reduction in overall HCV incidence in this population.

Another study presented at CROI indicates this may already be happening. Bart Rijnders and colleagues reported that new HCV infections among HIV-positive gay and bi men at health centers throughout the Netherlands have dropped by half in just over a year since the country instituted a policy of unrestricted access to direct-acting antivirals for hepatitis C treatment.

3/22/17

Source

E Hoornenborg, M Prins, RCA Achterbergh, et al. High prevalence of hepatitis-C virus among HIV negative MSM in Amsterdam PrEP Project. Conference on Retroviruses and Opportunistic Infections. Seattle, February 13-16, 2017. Abstract 519.