CROI 2012: Broadly Neutralizing Antibodies Can Help Fight HIV [VIDEO]


Recent discoveries about broadly neutralizing antibodies are helping advance the field of HIV vaccine development, according to Dennis Burton from the Scripps Research Institute and the Ragon Institute of MGH, MIT, and Harvard, who presented the annual Bernard Fields Lecture on Monday at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) in Seattle.

Viruses like HIV have evolved mechanisms to evade the human immune system, including "enormous variability, instability, and a sugar coating," Burton explained. Recent research has revealed dozens of neutralizing antibodies with activity against HIV, and the ability to induce them would likely provide protection against infection or disease progression.

This work "gives us whole sets of new vaccine targets," Burton said at a press conference preceding his talk. "I think it's is a very exciting time in the antibody side of HIV vaccine discovery."

Dennis Burton, CROI 2012 press conference, Seattle, March 5, 2012:



D Burton. Defying the Structure and Variability of HIV with Broadly Neutralizing Antibodies. 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012). Seattle, WA. March 5-8, 2012. Presentation 15.