Metabolic and Morphologic Complications of HIV and HAART


•	Useful as a surrogate marker to monitor the effects of disease progression and treatment by tracking changes in body cell mass¹
•	Most sensitive to changes in body water, and therefore, most accurate in estimating body compartments tied to these changes, such as lean body mass²
•	BIA is a suitable method for assessing body cell mass in HIV-infected patients without opportunistic infections³

1. Kotler DP et al. JPEN J Parenter Enteral Nutr. 1999;23:345-49. 2. Jacobs DO. JPEN J Parenter Enteral Nutr. 1993;17:401-3. 3. Sluys TEM et al. JPEN J Parenter Enteral Nutr. 1993;17:404-6.

• BIA is ideally suited as a surrogate marker to monitor the effects of disease progression and treatment in patients with HIV infection. It is able to do this by tracking changes in body cell mass.1

• Since it most sensitive to changes in body water, it has the most accuracy for estimating body compartments closely tied to these changes, such as lean body mass.2

• The technique is most suitable as a measurement of body cell mass in those patients who do not have opportunistic infections.3

• Unfortunately, BIA is not helpful in detecting those body composition changes found in the fat redistribution syndrome. It is also not able to detect the regional distribution or re-distribution of body fat that is characteristic of lipodystrophy.

References:

1. Kotler DP, Rosenbaum K, Allison DB et al. Validation of bioimpedance analysis as a measure of change in body cell mass as estimated by whole-body counting of potassium in adults. JPEN J Parenter Enteral Nutr. 1999;23:345-9.

2. Jacobs DO. Bioelectrical impedance analysis: a way to assess changes in body cell mass in patients with acquired immunodeficiency syndrome? JPEN J Parenter Enteral Nutr. 1993;17:401-3.

3. Sluys TEM, van der Ende ME, Swart GR et al. Body composition in patients with acquired immunodeficiency syndrome: a validation study of bioelectric impedance analysis. JPEN J Parenter Enteral Nutr. 1993;17:404-6.