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European
AIDS Clinical Society Issues New Guidelines for Treatment of HIV, HIV and Hepatitis
Coinfection, and Management of Metabolic Complications The European AIDS Clinical Society (EACS) has released new, revised guidelines for the treatment of HIV monoinfection in adults and HIV coinfection with hepatitis B and hepatitis C. Last updated in 2003, the new recommendations were presented October 26, 2007 at the 11th annual EACS conference in Madrid, Spain (October 24-27, 2007). Overall, the new guidelines reflect a more aggressive approach to initiation of treatment for HIV monoinfection, management of HIV-related metabolic complications, and treatment of HIV-HCV and HIV-HBV coinfection. The
guidelines state that HIV viral load suppression below 50 copies/mL should be
the goal of antiretroviral therapy for both treatment-experienced and treatment-naive
individuals. Treatment is recommended for patients with fewer than 350 cells/mm3,
bringing the European guidelines more in accord with U.S.
HIV treatment guidelines.
|
FDA-Approved
Treatments | |
Protease
Inhibitors | |
 | Agenerase (amprenavir) |
 | Aptivus (tipranavir) |
 | Crixivan (indinavir) |
 | Invirase (saquinavir hard gel) |
 | Kaletra (lopinavir/ritonavir) |
 | Lexiva (fosamprenavir) |
 | Norvir (ritonavir) |
 | Prezista (darunavir) |
 | Reyataz (atazanavir) |
 | Viracept (nelfinavir) |
Nucleoside
/ Nucleotide Reverse Transcriptase Inhibitors | |
 | Combivir (zidovudine/lamivudine) |
 | Epivir (lamivudine; 3TC) |
 | Emtriva (emtricitabine; FTC) |
 | Epzicom (abacavir + lamivudine) |
 | Retrovir (zidovudine; AZT) |
 | Trizivir (abacavir + zidovudine +lamivudine) |
 | Truvada (tenofovir / emtricitabine) |
 | Videx (didanosine; ddI) |
 | Viread (tenofovir) |
 | Zerit (stavudine; d4T) |
 | Ziagen (abacavir) |
non
Nucleoside Reverse Transcriptase Inhibitors | |
 | Rescriptor (delavirdine) |
 | Sustiva (efavirenz) |
 | Viramune (nevirapine) |
Entry
Inhibitors (including Fusion Inhibitors) | |
 | Fuzeon (enfuvirtide, T-20) |
 | Selzentry ( maraviroc) |
Fixed-dose
Combinations | |
 | Atripla (efavirenz + emtricitabine + tenofovir) |
| Combivir (zidovudine + lamivudine) |
| Trizivir (abacavir + zidovudine + lamivudine) |
| Truvada (tenofovir + emtricitabine) |