Depressive Symptoms, but Not Neurocognitive Impairment, Is Associated with Adherence to HAART

In the present study, the association of depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy (HAART) was evaluated in 135 HIV-infected persons.

Thirty percent reported nonadherence to HAART. Depressive symptoms (assessed with the Montgomery-Asberg Depression Rating Scale) and neurocognitive impairment (assessed with a neuropsychological test battery) were documented in 24% and 12%, respectively, of the study participants.

Nonadherence to HAART was independently associated with worse depression rating scale scores, acquisition of HIV through injection of drugs and complaints about impairment of sexual activity.

The presence of depressive symptoms, but not neurocognitive impairment, was associated with nonadherence.

Clinica delle Malattie Infettive, Universita Cattolica del Sacro Cuore, Rome, Italy.

09/17/04