|
Body
Shape Changes in a Cohort of HIV Positive and HIV Negative Injection
Drug Users
In
this study, researchers determined anthropometric measurements (including
height, weight, circumferences, and skin folds) and self-reported
symptoms related to body habitus changes in 324 HIV-seropositive
and HIV-seronegative inner city injection drug users (IDUs)
who participated in a substudy from the ALIVE (AIDS Linked to Intravenous
Experiences) cohort.
Participants
who reported lipoatrophy
(fat loss) in body parts had consistently lower anthropometric
measurements and those reporting adiposity (excess fat accumulation)
had correspondingly higher anthropometric measurements than participants
who did not report these changes.
Peripheral
lipoatrophy was more common among all HIV-seropositive than HIV-seronegative
participants, however, it was not associated with HAART (39% HIV-seronegatives;
58% HIV-seropositive not receiving HIV treatment [No Tx]; 49% HAART,
p = 0.04).
Central
adiposity
was more common among HAART (52%) than No Tx (26.6%) and HIV-seronegative
(42%) participants (p = 0.001). However, waist circumference,
while somewhat higher among HAART than No Tx participants, did not
differ significantly from HIV-seronegative participants (85.2 cm
HIV-seronegatives; 83.3 cm No Tx; 85.8 cm HAART).
A
large proportion of those who reported peripheral lipoatrophy also
reported central lipoatrophy (76.9% HIV-seronegatives; 69.6% No
Tx; 66.2% HAART).
A
large proportion of those who reported central adiposity also reported
adiposity of the peripheral sites (88.1% HIV seronegatives; 66.7%
No Tx; 74.3% HAART).
The
combination of lipoatrophy and adiposity was associated with HAART
treatment (6% HIV-seronegatives; 3% No Tx; 16% HAART, p =
0.002), but may be driven by the association with adiposity.
The
authors conclude, “These data suggest validity of self-reports for
body habitus changes among injection drug users.”
02/02/05
Reference
E
Smit and others. Body Habitus in a Cohort of HIV-Seropositive and HIV-Seronegative
Injection Drug Users. AIDS Patient
Care and STDs 19(1): 19-30. January 2005.
|
