Dyslipidemia: Evaluation of Serum Lipids

• The evaluation of patients with dyslipidemias begins by obtaining a baseline fasting-lipids profile.1 This includes total cholesterol, LDL, HDL, and triglycerides. If possible, all patients should receive this baseline testing prior to starting any type of antiretroviral therapy. Depending on baseline results, a lipid profile can then be performed every 3 to 6 months.

• In addition, the clinician must explore with patients any risk and lifestyle factors that may put them at increased risk for cardiovascular morbidity. This includes asking about their family history of heart disease, diabetes, and obesity. They should also be asked about their exercise and activity levels, and if they smoke or use alcohol.

• Finally, various comorbidities need to be identified that may complicate therapeutic interventions, such as a prior history of pancreatitis.

Reference:

1. Dube MP, Sprecher D, Henry WK et al. Preliminary guidelines for the evaluation and management of dyslipidemia in HIV-infected adults receiving antiretroviral therapy. Recommendations of the adult ACTG cardiovascular disease focus group. Clin Infect Dis. 2000;31:1216-24.