|
| •
|
Start
dietary and lifestyle changes
|
| •
|
Add
lipid-lowering agents (statins, fibrates)
|
| •
|
Modify
antiretroviral therapy: |
|
-
|
Substitute
NNRTIs for PIs
|
|
-
|
Substitute
abacavir for PIs
|
|
|
•
As in patients with high triglycerides, those with hypercholesterolemia
should start with dietary and lifestyle changes, such as smoking
cessation, weight loss, and limiting alcohol intake.1
• If these measures do not produce the desired results, lipid-lowering
agents, such as statins or fibrates, can be added.
• Adjustments in the patient’s antiretroviral therapy
regimen should also be considered, particularly if the patient is
currently receiving a PI-based regimen. A non-nucleoside agent,
such as efavirenz, can be substituted for the PI component. An alternative
option is to substitute the PI with abacavir.
Reference:
1. Dube MP, Sprecher D, Henry WK et al. Preliminary guidelines for
the evaluation and management of dyslipidemia in HIV-infected adults
receiving antiretroviral therapy. Recommendations of the adult ACTG
cardiovascular disease focus group. Clin Infect Dis. 2000;31:1216-24.
|
|
