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• This graph shows the correlation between changes in insulin
and tPA levels.1
• As you can see, the change in insulin area under the curve
(AUC) correlated significantly with changes in tPA antigen.
• Decreases in tPA were strongly associated with decreases in
insulin after response to metformin therapy. This suggests that decreasing
insulin may improve the cardiovascular risk profile in patients with
fat redistribution and insulin resistance.
Reference:
1. Hadigan C, Meigs JB, Rabe J et al. Increased PAI-1 and tPA antigen
levels are reduced with metformin therapy in HIV-infected patients
with fat redistribution and insulin resistance. J Clin Endocrinol
Metab. 2001;86:939-43.
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