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PAI-1
and tPA antigen levels significantly increased in patients with
fat redistribution |
| •
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Metformin
decreased tPA and PAI-1 levels
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Change
in insulin AIC correlated significantly with change in tPA
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Metformin
may reduce the risk for CVD
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• The study found that PAI-1 and tPA antigen levels were significantly
increased in patients with HIV-related fat redistribution when compared
to Framingham control subjects.
• Treatment with metformin resulted in decreased tPA and PAI-1
levels.
• In addition, the change in insulin area under the curve (AUC)
correlated significantly with change in tPA antigen.
• The results from this study suggest that, by reducing PAI-1
and tPA antigen concentrations, metformin may reduce the risk of cardiovascular
disease in patients with fat redistribution.
Reference:
1. Hadigan C, Meigs JB, Rabe J et al. Increased PAI-1 and tPA antigen
levels are reduced with metformin therapy in HIV-infected patients
with fat redistribution and insulin resistance. J Clin Endocrinol
Metab. 2001;86:939-43.
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