|
|
 |
Relative
Risk Compared with ZDV/3TC- Containing
Regimens
| Drug |
RR
(95% CI; p value) |
| d4T/3TC |
11.6
(1.5-87.9; p=0.018) |
| d4T/ABC |
15.0
(1.4-165.0; p=0.027) |
| d4T/ddI |
36.3
(4.6-283.7; p=0.001) |
| d4T/ddI/3TC |
147.9
(17.3-1265.6; p<0.0001) d |
•
The relative risk of hyperlactatemia was compared for a number of
regimens to zidovudine and 3TC.1
• Again, all of the d4T regimens had an increased relative risk
associated with them.
• These data seem to suggest an increased risk of hyperlactatemia
from d4T-containing regimens.
Reference:
1. Longergan JT, Havlir D, Behling C et al. Incidence and outcome
of hyperlactatemia associated with clinical manifestations in HIV-infected
adults receiving NRTI-containing regimens. Program and abstracts of
the 8th Conference on Retroviruses and Opportunistic Infections, Chicago,
IL; February 4-8, 2001. Abstract 624.
|
|
|
|
