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Switching
d4T for ZDV or ABC in Patientswith
Fat Wasting – Effect on Lactate
•
These are results from a study by Saint-Marc and colleagues who examined
the effect of stopping d4T in order to reverse peripheral fat wasting.1
As part of the study, lactate levels were measured.
• In patients who were either PI-naïve or PI-experienced,
there was a decrease in blood lactate levels over a period of time
after d4T was discontinued.
• It should be noted that these were asymptomatic lactate levels.
This particular study was looking at what happens in relationship
to increased lactate after d4T is stopped.
• Nevertheless, this data seem to suggest that there may be an
increased prevalence of lactate when d4T-containing regimens are used.
Reference:
1. Saint-Marc T, Partisani M, Poizot-Martin I et al. Reversibility
of peripheral fat wasting (lipoatrophy) on stopping stavudine therapy.
Program and abstracts of the 7th Conference on Retroviruses and Opportunistic
Infections, San Francisco, CA; January 30-February 2, 2000. Abstract
52.
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