Salvage Therapy with Amprenavir, Lopinavir and Ritonavir 400 mg/d Shows Significant Virological Efficacy

The objectives of the current study were to compare the antiviral efficacy of a salvage therapy combining lopinavir (Kaletra) and amprenavir (Agenerase) with 200 mg/d or 400 mg/d ritonavir (Norvir), together with nucleoside reverse transcriptase inhibitors (NRTI), over a 26-week period in HIV-infected patients in whom multiple antiretroviral regimens had failed.

This was a Phase IIb, randomized, open-label, multicentre trial.

Patients were eligible if they had <500 CD4+ cells/mm3 and >4 log10 copies/ml HIV-RNA after treatment with at least two protease inhibitors (PIs) and one non-nucleoside reverse transcriptase inhibitor.

Results

At baseline (n=37), the median CD4+ cell count was 207/mm3 and the median plasma HIV-1 RNA level was 4.7 log10 copies/ml; the median number of PI mutations was seven and the median decrease in phenotypic susceptibility to lopinavir and amprenavir was 9.7 and 2.6, respectively.

The mean number of antiretrovirals received prior to randomization was 7.7.

The fall in the median HIV-1 RNA level at week 26 was -1.4 log10 copies/ml in the 200 mg/d ritonavir group and -2.5 log10 copies/ml in the 400 mg/d group (P=0.02).

Viral load fell below 50 copies/ml in 32% and 61% of patients, respectively (P=0.07).

After adjustment for the ritonavir dose, a smaller number of PI mutations was the only baseline characteristic associated with a better virological response at week 26.

Amprenavir concentrations were significantly lower in presence of lopinavir.

The lopinavir inhibitory quotient at week 6 correlated weakly with the change in the HIV-RNA level at week 26.

Conclusion

Combination of amprenavir, lopinavir and 400 mg/d ritonavir shows significant virological efficacy without increased toxicity in HIV-infected patients in whom multiple antiretroviral regimens have failed.

Service de Maladies Infectieuses, Hopital Saint-Antoine, Assistance Publique-Hopitaux de Paris, Paris, France.

10/15/04

Reference
G Raguin and others (and the Puzzle 1 Study Group). Salvage therapy with amprenavir, lopinavir and ritonavir 200 mg/d or 400 mg/d in HIV-infected patients in virological failure. Antiviral Therapy 9(4): 615-25. August 2004.