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Laboratory
Tests for Monitoring HIV-1 Infection
By
Daniel R. Kuritzkes, MD
Director
of AIDS Research, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School
I.
Drug Resistance Testing in HIV-1 Infection
 Clinical
Significance of Drug Resistance in HIV-1 Infection
Genotype
and Phenotype
How
Resistance Tests are Done
›
Genotypic Assays
› Phenotypic Assays
Genotyping
vs Phenotyping: Advantages and Disadvantages
Interpreting
Resistance Tests
› The Virtual Phenotype
Prognostic
Value of Resistance Testing
Prospective
Trials of Drug Resistance Testing
›
Viradapt
› GART
› HAVANA
› VIRA3001
› NARVAL
The
Inhibitory Quotient (IQ)
When
and How to Use Resistance Testing
II.
Diagnosing HIV Infection
HIV
ELISAs and Western Blots
Rapid
HIV Tests
Home
Testing for HIV Infection
Virus
Culture
p24
Antigen Assays
PCR
Assays
›
Qualitative Assays for Proviral HIV-1 DNA
III.
Virus Load Testing
Clinical
Utility of Plasma HIV-1 RNA Monitoring
Sample
Collection
IV.
Immunologocal Testing
CD4
Counts
Other
Flow Cytometry Markers
Functional
Assays
Proliferation
Assays
Cytotoxic
T Lymphocyte Assays
V.
Therapeutic Drug Level Monitoring
VI. Glossary of
Terms
VII.
References
VIII.
Tables
1.
Major Drug Resistance Mutations
2.
Web Sites
for Interpreting Resistance Test Results
3.
Characteristics
of Assays for Quantification of
› . Plasma
HIV-1 RNA
4.
Association
of Plasma HIV-RNA Level with Decline
› . in
CD4+ Cell Count and Risk of AIDS and Death
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2002 by HIV and Hepatitis.com. All Rights Reserved
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