Glossary of Terms


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Table 1. Major Drug Resistance Mutations

Nucleoside RT Inhibitors

Drug

Zidovudine

Didanosine

Zalcitabine

Lamivudine

Abacavir

Stavudine

Multinucleoside

Resistance

Tenofovir

DAPD

Mutations

M41L, D67N, K70R, L210W, T215Y or F, K219Q, E, or RE44D, V118I, H208Y

K65R, L74V, M184V

K65R, L74V, M184V

M184V or I

K65R, L74V, Y115F, M184V

K70R, T215Y or F, V75T

Q151M (usually together with A62V, V75I, 77L, F116Y)

T69SSS or T (together with 62V, 210W, 215Y or F)

K65R

K65R

Non-nucleoside RT Inhibitors

Delavirdine

Efavirenz

Nevirapine

L100I, K103N, V106A, Y181C/I, 230L, P236L

L100I, K103N, V108I, Y188C/L/H, G190A/S, P225H, Jar

K103N, V106A, Y181C/I, Y188C/L/H, G190A/S

Protease Inhibitors

Amprenavir

Indinavir

Lopinavir

Nelfinavir

Ritonavir

Saquinavir

M46I/L, I47V, I50V, I84V

L10I, M46I/L, I54V/L, A71V/T, V82A/T/F, I84V

D30N, N88D or S, L90M

V82A/T/F, I84V

G48V, L90M

Mutations shown are the major mutations most commonly selected by each drug. Additional minor mutations may also accumulate and confer higher levels of resistance to the drug. Likewise, mutations selected by one drug may confer cross-resistance to another drug, but patterns of cross-resistance are not indicated in this table. For a more complete list of mutations see Hirsch et al JAMA 2000;283:2417-26; the resistane database at www.hiv.lanl.gov, or the Stanford PR and RT sequence database http://hivdb.stanford.edu/hiv/.

4/15/01