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and Hepatitis.com Coverage of the
50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010)
Experimental Drug LMV-601 Inhibits HPV Replication and Abnormal Cell Growth in Laboratory Study
papillomavirus can cause abnormal cell growth ranging from warts to
cervical or anal cancer. Numerous studies have shown that cervical and
anal dysplasia, or pre-cancerous cell changes, are more common among
HIV positive compared with HIV
Eberhard Amtmann from the German Cancer Research Center in Heidelberg and colleagues looked at the effect of the experimental PC-PLC inhibitor LMV-601 on cultured human cervical cancer cells.
After infection, HPV genetic material (DNA) is integrated into the chromosome of a host cell, the researchers explained in a press release issued by ICAAC. As a consequence, a specific part of the viral genetic sequence -- known as an oncogene -- transforms normal cervical cells into immortalized cells that multiply indefinitely. Normal cells have limited growth potential; being immortal is one of the prerequisites for becoming a cancer cell.
The investigators previously showed in another lab study that LMV-601 inhibits transcription of the HPV-31 genome in pre-malignant transformed human cervical epithelial cells. HPV DNA replication was stopped, and with prolonged treatment the cells lost their transformed appearance and finally became senescent, or exhausted, and stopped dividing.
present study, the team investigated whether LMV-601 is also active
against other cancer-causing HPV types. This in vitro analysis used
CaSki (infected with HPV-16) and HeLa (infected with HPV-18) cells derived
from patients with high-risk HPV who developed cervical cancer. HPV
types 16 and 18 cause 75% of cervical cancer cases in North America,
according to the researchers.
In more detail:
PC-PLC inhibitor LMV-601 is active on at least 3 different high risk
HPV types (16, 18 and 31) found in the majority of cervical cancers,"
the researchers concluded. "With prolonged treatment, HPV transformed
pre-malignant and malignant cells become senescent."