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and Hepatitis.com Coverage of the
18th Conference on Retroviruses and
Opportunistic Infections (CROI 2011)
February 27 - March 2, 2011, Boston, MA
HIV/HCV Coinfected People Have Higher Risk of Bone Loss
As described at the recent 18th Conference on Retroviruses and Opportunistic Infection (CROI 2011), researchers from Massachusetts General Hospital and the University of Pennsylvania compared fracture rates among HIV/HCV coinfected people on antiretroviral therapy (ART) and those with just one of these viruses.
This retrospective analysis looked at U.S. Medicaid participants age 18 and older from California, Florida, New York, Ohio, and Pennsylvania, between the years 1999 and 2005. A total of 36,950 patients were HIV/HCV coinfected, 95,827 had only HIV, 276,901 had only HCV, and 366,829 had neither virus. About 30% to 50% in the various cohorts were women, and the average age range was about 40 to 50 years.
The researchers used ICD-9 diagnosis codes in patient medical records to determine the number of hip and vertebral spine fractures, and ART use was determined based on pharmacy claims.
Based on these findings, the researchers concluded, "Antiretroviral-treated HIV/HCV coinfected patients experienced increased rates of hip fractures compared to HCV monoinfected, antiretroviral-treated HIV monoinfected, and uninfected persons."
"Mechanisms for the association between HCV and fractures are unclear," they added, but "[h]igher rates of fractures among HIV/HCV patients might be due to additive effects of HIV infection, HCV infection, and ART."
Investigator affiliations: Massachusetts General Hospital, Boston, MA; University of Pennsylvania, Philadelphia, PA.