What is Crixivan?
CRIXIVAN is a
protease (PRO-tee-ase) inhibitor used in combination
with other anti-HIV drugs for the treatment of
HIV. CRIXIVAN can help reduce your chances of
getting illnesses associated with HIV. CRIXIVAN
can also help lower the amount of HIV in your
body (called viral load) and raise your CD4 (T)
cell count. CRIXIVAN may not have these effects
in all patients.
not a cure for HIV or AIDS
not reduce your chances of transmitting HIV
be taken only in combination with other drugs
for HIV infection
Taking Crixivan with foods?
some HIV medicines to work, you have to take them
with food. Others must be taken on an empty stomach.
If youre on CRIXIVAN, you can take it with
a light meal or on an empty stomach, whichever
is easier for you. The rest of the day, when youre
not taking your CRIXIVAN, you can eat whatever
you are going to eat a big meal around your dose
of CRIXIVAN, remember that CRIXIVAN works best
when you take it 1 hour before eating a big meal
or 2 hours after eating a big meal.
because foods high in calories, fat, or protein
get in the way of CRIXIVAN, meaning it may not
get into your bloodstream and get to work. You
can still eat things like bacon and eggs for breakfast,
or a pizza or burger now and then for lunch or
dinner. Just make sure you take CRIXIVAN 1 hour
before or 2 hours after that kind of meal.
can even eat a little something with your dose
of CRIXIVAN. Just make it light. Meals like plain
spaghetti with tomato sauce, or a corn tortilla
with steamed rice and salsa. Or snacks like pretzels
and soda, plain popcorn, or fat-free pudding.
have more to choose from, too! Check out the food
list made up especially for people who want to
eat a light meal when taking CRIXIVAN. Ask your
healthcare provider about this food list.
What Are the Side Effects?
Possible Side Effects
Do not take CRIXIVAN® (indinavir sulfate)
if you have had a serious allergic reaction to
CRIXIVAN or any of its components.
patients treated with CRIXIVAN developed kidney
stones. For some, this leads to more severe kidney
problems, including kidney failure, inflammation
of the kidneys, or kidney infection, which sometimes
spreads to the blood. Drinking at least six 8-ounce
glasses of liquid (preferably water) each day
should help reduce the chance of forming a kidney
some patients experienced rapid breakdown of red
blood cells (hemolytic anemia), which in some
cases was severe or resulted in death; some had
liver problems, including liver failure and death.
and high blood sugar (hyperglycemia) have occurred
in patients taking protease inhibitors. In some
of these patients, this led to ketoacidosis, a
serious condition caused by poorly controlled
blood sugar. Some patients had diabetes before
starting protease inhibitors; others did not.
Some patients required adjustments to their diabetes
medication. Others needed new diabetes medication.
have been reports of increased bleeding in patients
with hemophilia A and B.
muscle pain and weakness have occurred in patients
taking protease inhibitors, including CRIXIVAN,
together with some of the cholesterol-lowering
medicines called statins. Call your
doctor if you develop severe muscle pain or weakness.
in body fat have been seen in some patients taking
antiretroviral therapy. These changes may include
increased amount of fat in the upper back and
neck (buffalo hump), breast, and around
the trunk. Loss of fat from the legs, arms, and
face may also happen. The cause and long-term
effects of these conditions are not known at this
in bilirubin (one laboratory test of liver function)
have occurred in approximately 14% of patients,
and, on rare occasions, a patient may develop
yellowing of the skin and/or eyes.
effects occurring in 2% or more of patients included
abdominal pain, fatigue or weakness, low red blood
cell count, flank pain, painful urination, feeling
unwell, nausea, upset stomach, diarrhea, vomiting,
acid regurgitation, increased or decreased appetite,
back pain, headache, dizziness, taste changes,
rash, itchy skin, yellowing of the skin and/or
eyes, upper respiratory infection, dry skin, and
Other side effects reported since CRIXIVAN has
been marketed include allergic reactions; severe
skin reactions; yellowing of the skin and/or eyes;
heart problems, including heart attack; stroke;
abdominal swelling; indigestion; inflammation
of the kidneys; inflammation of the pancreas;
joint pain; depression; itching; hives; change
in skin color; hair loss; ingrown toenails with
or without infection; crystals in the urine; painful
urination; numbness of the mouth; and increased
you should not take with Crixivan
Ergot medications (eg, Wigraine®, Cafergot®,
D.H.E. 45, Migranal®, Ergotrate®, Methergine®)
Rifadin®, Rifamate®, Rifater®, Rimactane®
you can take with Crixivan
Epivir® (lamivudine, 3TC)
Lipitor® (atorvastatin) *
Mycobutin® (rifabutin) *
Nizoral® (ketoconazole) *
Ortho-Novum 1/35® (oral contraceptive)
Sporanox® (itraconazole) *
Sustiva® (efavirenz) *
Videx® (didanosine) *
Zerit® (stavudine, d4T)