Intelence is a non-nucleoside
reverse transcriptase inhibitor (NNRTI) manufactured
by Tibotec, a subsidiary of Johnson & Johnson.
It was approved by the U.S. Food and Drug Administration
(FDA) in January 2008. Intelence is approved
for treatment-experienced patients who have
HIV strains that are resistant to multiple antiretroviral
drugs, including other NNRTIs. It is not yet
approved for people with drug-sensitive HIV
strains, such as those starting antiretroviral
therapy for the first time.
Intelence works by blocking
HIVs reverse transcriptase enzyme. After
HIV's genetic material is deposited inside a
cell, its RNA must be converted (reverse transcribed)
into DNA. NNRTIs stop this process and prevent
HIV from infecting the CD4 cell and producing
new virus particles.
Intelence must be used
in combination with other HIV drugs.
What is already known
The Intelence dose is
two 100 mg tablets taken by mouth twice a day.
It should be taken following a meal (e.g., breakfast
The tablets should be
swallowed whole, with liquid such as water.
The tablets should not be chewed. If you are
unable to swallow the tablets whole, you can
dilute the tablets in a glass of water. Stir
the water well, until it looks milky, then drink
the mixture immediately. Make sure that there's
no medication residue remaining in the glass
(add additional water and then mix and swallow
Intelence is active against
HIV strains resistant to other antiretrovirals,
including many strains that are resistant to
the NNRTIs Sustiva (efavirenz), Viramune (nevirapine)
and Rescriptor (delavirdine). Drug-resistance
testing can be used to determine how effective
Intelence will be against HIV, if other NNRTIs
have been used in the past.
Intelence is not yet approved
for people with HIV that have no, or limited,
resistance to other available antiretroviral
drugs. This includes HIV-positive people beginning
treatment for the first time. However, a clinical
trial evaluating Intelence's safety and effectiveness
in first-time treatment takers is being conducted.
Intelence is not yet approved
for use in HIV-positive children. To learn more
about treatment options for children, click
What about drug interactions?
of the way Intelence is metabolized (broken
down) in the body, it can interact with many
other medications used to treat HIV, AIDS-related
complications and other diseases. Intelence
may cause blood levels of other medications
to become too low (which can decrease their
effectiveness) or high (which can increase the
risk of side effects). Similarly, other medications
may cause blood levels of Intelence to become
too low or high.
the time of Intelence's approval in January
2008, there were no known "contraindications,"
meaning that there were no known medications
that must be avoided while taking Intelence.
However, there are a number of medications that
are not yet recommended for use in combination
with Intelence, due to serious drug interactions,
until additional dosing studies are successfully
can interact with several HIV medications. Intelence
should not be combined with the following: Norvir
(ritonavir)-boosted Aptivus (tipranavir), Norvir-boosted
Lexiva (fosamprenavir) or Norvir-boosted Reyataz
(atazanavir); any protease inhibitors given
without a boosting dose of Norvir; or any of
the other approved NNRTIs.
can be combined with any of the approved nucleoside
reverse transcriptase inhibitors (NRTIs). It
can also be combined with Norvir-boosted Prezista
(darunavir) or Norvir-boosted Invirase (saquinavir)
without having to adjust the doses of any of
the drugs being used. Intelence can also be
combined with the integrase inhibitor Isentress
(raltegravir), without requiring dose adjustments.
(lopinavir plus ritonavir) should be used cautiously
with Intelence, given that it can raise Intelence
blood levels 85 percent and potentially increase
the risk of Intelence side effects. While it
is possible that Intelence can be combined with
Selzentry (maraviroc), official dosing recommendations
have not yet been made (if using Intelence without
a Norvir-boosted protease inhibitor, the Selzentry
dose will likely be 600 mg, taken twice a day;
if using Intelence with a Norvir-boosted protease
inhibitor, the Selzentry dose will likely be
150 mg, taken twice a day).
can interact with Biaxin (clarithromycin), Rifadin
(rifampin), Priftin (rifapentine) and Mycobutin
(rifabutin)medications used to treat TB,
MAC, and other bacterial infections. Zithromax
(azithromycin) should be used as an alternative
to Biaxin. Because Rifadin and Priftin can greatly
reduce levels of Intelence in the bloodstream,
they should not be used at the same time. If
Intelence is being used with a Norvir-boosted
protease inhibitor, Mycobutin should not be
used. If Intelence is being used without a Norvir-boosted
protease inhibitor, a Mycobutin dose of 300
mg twice a day is recommended.
can interact with several medications used to
treat thrush (candidiasis) and other fungal
infections, including Diflucan (fluconazole),
Sporanox (itraconazole), Nizoral (ketoconazole),
Noxafil (posaconazole) and Vfend (voriconazole).
Dose adjustments of antifungal medications may
need to be altered if used in combination with
commonly used to treat drug addiction, can be
taken with Intelence.
can interact with a number of heart medications,
including Vascor (bepridil), Tambocor (flecainide)
and Rythmol (propafenone). Intelence can reduce
levels of these medications in the bloodstream,
potentially making them less effective. Monitoring
blood levels of these heart medications is recommended
if using them in combination with Intelence.
anticonvulsants Tegretol (carbamazepine), Luminal
(phenobarbital) and Dilantin (phenytoin) should
not be used in combination with Intelence.
drugs, also known as "statins," can
interact with Intelence. Intelence may decrease
blood levels of Zocor (simvastatin) and Mevacor
(lovastatin). Lescol (fluvastatin) may increase
levels of Intelence in the blood stream. Intelence
can be given with Lipitor (atorvastatin), although
it may be necessary to adjust the dose of Lipitor
if cholesterol levels do not improve. It is
not expected that Intelence will interact with
Pravachol (pravastatin) or Crestor (rosuvastatin).
(sildenafil), Levitra (vardenafil) and Cialis
(tadalafil) levels in the bloodstream may decrease
when combined with Intelence. Doses of these
medications may need to be adjusted.
products can also interact with Intelence. St.
John's wort should not be used with Intelence,
since it can reduce the amount of Intelence
in the bloodstream.
drug interactions are possible. Be sure to tell
your doctor about all the medications you are
taking (or plan to take), including those you
buy over the counter at your pharmacy or health-food
store, while taking Intelence.
What is known about side
most common side effects reported in clinical
trials using Intelence were rash (16.9 percent)
and nausea (13.9 percent). If you develop a
rash while taking Intelence, notify your health
possible side effects of Intelence include diarrhea,
vomiting, abdominal pain, tiredness, tingling
or pain in hands or feet, numbness, headache
and high blood pressure.