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Rilpivirine (Edurant,TMC278)
FDA Approves NNRTI Rilpivirine (Edurant, TMC278) 5-20-2011 Low Vitamin D Levels Less Likely with Rilpivirine than Efavirenz 3-18-2011 Evaluation Resumes for Gilead's Rilpivirine/Truvada Single-tablet Regimen 2-18-2011 FDA Declines New Drug Application for Rilpivirine/Truvada Combination Pill 1-28-2011 Gilead Submits Rilpivirine (TMC278) Single-tablet Regimen for FDA Approval 11/30/2010 Rilpivirine Failure Linked to High Viral Load and Poor Adherence 9/24/2010 Gilead Files for European Approval of Single-tablet Regimen Containing New NNRTI Rilpivirine 9/10/2010 New NNRTI Rilpivirine (TMC278) Shows Potent Antiviral Activity and Good Tolerability in Phase 3 Trials, FDA Application Submitted 7/26/2010 Pooled Week 48 efficacy and safety results from ECHO and THRIVE, two double-blind, randomised, Phase III trials comparing TMC278 versus efavirenz in treatment-naïve, HIV-1-infected patients 7/23/2010 Pharmacokinetic interaction study between TMC278, a next-generation NNRTI, and methadone 7/23/2010 Relative bioavailability of a concept paediatric formulation of TMC278, an investigational NNRTI 7/23/2010 Gilead Working on Once-daily Coformulation of Tibotec's NNRTI Rilpivirine (TMC278) plus Tenofovir/emtricitabine 4/24/2010 Experimental NNRTI Rilpivirine (TMC278) Shows Efficacy Comparable to Efavirenz (Sustiva) at 96 Weeks, but with Fewer Side Effects 12/08/2009 Depot Formulation of Rilpivirine (TMC278) May Offer Months of Sustained Anti-HIV Activity with a Single Injection 8/29/2008 Investigational Next-generation NNRTI Rilpivirine (TMC278) Demonstrates Potent Antiviral Activity at 96 Weeks in Treatment-naive Individuals 8/08/2008 Tibotec Opens Enrollment for 2 Phase III Trials of Experimental NNRTI Rilpivirine (TMC278) in Treatment-naive Patients 7/22/2008 Long-acting TMC278, a parenteral depot formulation delivering sustained NNRTI plasma concentrations in preclinical and clinical settings 2/20/2008