French researchers investigated the incidence of both AIDS-defining
sarcoma, non-Hodgkin lymphoma, and cervical cancer)
and non-AIDS-defining cancers (Hodgkin's lymphoma, lung
cancer, liver cancer, and anal cancer) in 52 278 patients
followed up in the French Hospital Database on HIV cohort
current HIV treatment guidelines
recommend starting antiretroviral therapy (ART) in patients
when their CD4 cell count is approximately 350 cells/mm3.
"Our results suggest that ART would be most beneficial
if it restores or maintains the CD4 cell count above 500
cells/mm3, thereby indicating earlier diagnosis of HIV infection
and earlier treatment initiation", the authors wrote.
to the authors' summary.
M Guiguet, F Boué, J Cadranel, and others (on behalf
of the Clinical Epidemiology Group of the FHDH-ANRS CO4
cohort). Effect of immunodeficiency, HIV viral load, and
antiretroviral therapy on the risk of individual malignancies
(FHDH-ANRS CO4): a prospective cohort study. The Lancet
Oncology. Early Online Publication, 8 October 2009.