|
|
 |
|
| •
|
Medications
have direct effect |
| •
|
Fat
distribution is affected: |
|
-
|
Association
between truncal obesity and insulin resistance |
|
-
|
Syndrome
X
|
|
-
|
Type
II diabetes
|
| •
|
Primary
problem is insulin resistance |
|
|
•
The pathogenesis behind these glucose abnormalities is not well understood.
It is clear, however, that various antiretroviral medications, particularly
the protease inhibitors, have a direct effect on the development of
insulin resistance in these patients.
• Along with this insulin resistance is an effect on fat distribution.
There has always been a well-known association between truncal obesity
and insulin resistance, which combine to produce the characteristic
Syndrome X and Type II, adult-onset diabetes.
• Although various glucose abnormalities are observed in patients
with HIV infection, the main problem appears to be insulin resistance.
|
|
|
|
