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AIDS 2014: Switching ART with Suppressed Viral Load Linked to Treatment Failure

People who switch away from their initial antiretroviral therapy (ART) regimen when their viral load is undetectable may have a higher likelihood of subsequent virological failure, researchers reported at the 20thInternational AIDS Conference last week in Melbourne. However, the association varied across groups and the researchers suggested their findings may reflect issues such as adherence difficulties or treatment changes due to pregnancy.

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Of Guidelines Targets, and Resources -- Documents that Defined AIDS 2014

If there was a phrase that defined the 20th International AIDS Conference last week in Melbourne -- one that surfaced in every few presentations and kept turning up in documents -- it was "key affected populations." New World Health Organization (WHO) guidelines released in conjunction with AIDS 2014 recommend pre-exposure prophylaxis (PrEP) as an option for gay men at risk for HIV infection and naloxone to prevent overdoses among people who inject drugs (PWID).

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AIDS 2014: iPrEx PrEP Users Talk Condoms, Pills, Anxiety, and Relief

Interviews with participants in the U.S. sites of the iPrEx study of pre-exposure prophylaxis (PrEP) show that participants who took it mainly used it as an additional source of reassurance rather than to replace whatever risk-management strategy they were currently using to avoid HIV infection, researchers reported at the 20th International AIDS Conference last week in Melbourne.

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AIDS 2014: WHO Guidelines Recommend PrEP as Prevention Option for Gay Men [VIDEO]

The World Health Organization (WHO) issued new guidelines for key populations affected by HIV/AIDS prior to the 20th International AIDS Conference held last week in Melbourne, Australia. Among the biggest changes -- and th eone that has garnered the most attention and controversy -- is a recommendation that gay men who are at risk for HIV infection should consider pre-exposure prophylaxis (PrEP) as an additional prevention option.

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AIDS 2014: More Data Suggest Increased HIV Risk from Injectable Contraceptives

A sophisticated meta-analysis, pooling individual-level data on 37,000 women, has found that the use of DMPA injectable hormonal contraception is linked with a higher rate of new HIV infections among women, researchers reported at the 20th International AIDS Conference last week in Melbourne. However, the World Health Organization (WHO) announced at the same session that its guideline supporting the provision of this contraceptive to women at risk of HIV infection remains unchanged.

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AIDS 2014: Dolutegravir Demonstrates Good Efficacy Despite Resistance

Antiretroviral regimens containing the recently approved HIV integrase inhibitor dolutegravir (Tivicay) demonstrated high rates of viral suppression even in treatment-experienced people who were resistant to NRTIs. Among people starting treatment for the first time, no resistance was detected through 96 weeks, according to study findings presented at the 20th International AIDS Conference last week in Melbourne.

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UNAIDS Gap Report Finds Half of HIV+ People Worldwide Are Unaware of Status

Half of people living with HIV worldwide -- or approximately 19 million -- do not know they are infected, preventing them from receiving life-saving treatment and contributing to viral transmission, according to the latest UNAIDS Gap Report released in advance of the 20th International AIDS Conference last week in Melbourne. The report also outlines progress, including the 13 million people who had access to antiretroviral therapy at the end of 2013.

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