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Helicase Inhibitor Pritelivir Shows Promise Against Genital Herpes

Pritelivir, a helicase inhibitor that interferes with viral replication, reduced the rate of herpes simplex virus type 2 (HSV-2) genital shedding, which has the potential to reduce sexual transmission, according to a small study described in the January 16, 2014, New England Journal of Medicine.

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CDC STD Report Shows Rise in Gonorhea, Syphilis

The U.S. Centers for Disease Control and Prevention (CDC) this week released its annual sexually transmitted disease (STD) surveillance report on chlamydia, gonorrhea, and syphilis, showing that the latter two infections have increased by 4% and 11%, respectively, with the rise in syphilis occurring primarily among gay and bisexual men.

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Gonorrhea May Become Untreatable Due to Resistance, Experts Warn

Neisseria gonorrhoeae,the bacteria that cause gonorrhea, are becoming increasingly resistant to existing drugs and more difficult to treat in the U.S., public health experts warn in the February 9, 2012, New England Journal of Medicine.

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ICAAC 2013: Novel Therapeutic Vaccine Reduces Genital Herpes Shedding

An experimental immune-modulating vaccine significantly reduced shedding of herpes simplex virus type 2 (HSV-2) in people with recurrent genital herpes, according to a late-breaker presentation at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) this week in Denver. The vaccine appeared safe and well-tolerated.

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STD Report Shows Small Rise Overall, Higher Rates for People of Color, Young Gay Men

Reported cases of gonorrhea rose slightly and syphilis declined somewhat during 2010, but the syphilis rate among young black men has increased dramatically over the past 5 years, largely driven by increases among men who have sex with men (MSM), according to the latest sexually transmitted disease (STD) surveillance report from the Centers for Disease Control and Prevention (CDC).alt

New Antibiotic Regimens Shown Effective Against Drug-resistant Gonorrhea

A pair of antibiotic regimens using the existing drugs gentamicin or gemifloxacin plus azithromycin work against resistant gonorrhea, but come with side effects, CDC and NIH researchers reported at the 20th Meeting of the International Society for Sexually Transmitted Diseases Research this week in Vienna.

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Sexual Partners Should Get Expedited Treatment for Chlamydia and Gonorrhea

Male sexual partners of women diagnosed with chlamydia or gonorrhea should be prescribed antibiotics in an effort to prevent passing infections back and forth, according to new guidelines from the American College of Obstetricians and Gynecologists (ACOG).alt

Drug Resistant Gonorrhea Makes its Way into North America

The first documented failure of oral treatment for gonorrhea in North America has been reported in Toronto. The article, Neisseria gonorrhoeae Treatment Failure and Susceptibility to Cefexime in Toronto, Canada, published in the January 9, 2013, Journal of the American Medical Association, provides support for growing concern surrounding the second most prevalent bacterial sexually transmitted infection in the world.
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Genital Herpes Virus Can Spread Despite Lack of Symptoms

People without genital sores or other symptoms can still shed and transmit herpes simplex virus type 2 (HSV-2) during sex, according to a recent U.S. study. alt

CDC Recommendation: Dual Treatment to Curb Tide of Drug-Resistant Gonorrhea

Increasing fears about the emergence of antibiotic resistant gonorrhea in the U.S. have prompted new treatment and surveillance recommendations from the Centers for Disease Control and Prevention (CDC). Gail Bolan, director of the agency's Division of STD Prevention, called the move "a critical pre-emptive strike to preserve the last effective treatment option." alt

Oral Tenofovir Does Not Reduce Herpes Virus Shedding

HIV positive people who took tenofovir (Viread, also in the Truvada and Atripla combination pills) as part of their antiretroviral regimen were no less likely to shed herpes simplex virus 1 or 2 (HSV-1 or HSV-2) than individuals using non-tenofovir regimens, according to research described in the January 14, 2011, issue of AIDS. These findings are notable because a recent microbicide study found that a tenofovir gel reduced the likelihood of HSV-2 infection.

WHO Warns of Global Threat of Drug-resistant Gonorrhea

Multidrug-resistant gonorrhea is a growing concern worldwide and millions of people may be at risk of running out of treatment options unless urgent action is taken, according to an alert issued this week by the World Health Organization (WHO).alt

U.S. Sexually Transmitted Disease Rates Remain High, with a Resurgence of Syphilis among Gay Men

Rates of 3 sexually transmitted diseases (STDs) -- chlamydia, gonorrhea, and syphilis -- remain high in the U.S., according to the latest epidemiological data issued last week in a report by the Centers for Disease Control and Prevention (CDC). These infections can be cured, but can cause serious complications if untreated and can increase the risk of HIV acquisition and transmission. High STD rates among African-Americans and teens are particularly alarming, and men who have sex with men account for the greatest prevalence of syphilis, which has made a comeback after nearly being eliminated.

Researchers Report Setbacks on Herpes Simplex Vaccine and Treatment

An experimental herpes simplex virus (HSV) vaccine partially protected women against infection with HSV type 1 but not type 2, according to a recent report in the New England Journal of Medicine. Another recent study found that antiviral treatment with acyclovir (Zovirax) or valacyclovir (Valtrex) did not prevent periodic HSV-2 reactivation and viral shedding.alt