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Truvada for PrEP Not Linked to Kidney Impairment, Resistance Is Rare

Truvada (tenofovir/emtricitabine) used for pre-exposure prophylaxis (PrEP) was not associated with clinically relevant declines in kidney function through 36 months in a large clinical trial, researchers recently reported. A related study found that drug resistance is rare among PrEP users, but it can occur in people who have acute HIV infection when they start Truvada and those who become infected despite PrEP.

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Only 1 HIV Infection Due to Occupational Exposure Since 1999

A total of 58 confirmed and 150 possible cases of occupationally acquired HIV infection among healthcare workers were reported to the Centers for Disease Control and Prevention (CDC) between 1985 and 2013, but only a single confirmed case has occurred since 1999, according to a report in the January 9 Morbidity and Mortality Weekly Report. Investigators attributed the recent lack of infections to improved precautions and antiretroviral post-exposure prophylaxis (PEP). 

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HIV PrEP Forum Discusses Research, Personal Experiences, and Access

Nearly 100 people gathered on January 11 in San Francisco's Castro neighborhood to learn about the latest research on HIV pre-exposure prophylaxis -- better known as PrEP -- and how they can get help paying for it.

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Long-acting Injectable Cabotegravir Shows Promise as PrEP in Monkey Studies

A long-acting injected formulation of the HIV integrase inhibitor cabotegravir (GSK1265744) prevented infection of most macaque monkeys vaginally exposed to an HIV-like hybrid virus at drug concentrations achievable with monthly dosing, according to a pair of studies published in the January 14 issue of Science Translational Medicine.

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Meta-Analysis Shows Injectable Hormonal Contraception Linked to HIV Infection Risk

Women who use the long-acting injectable contraceptive Depo-Provera had a modest but significant increase in the risk of contracting HIV infection, according to a meta-analysis of 12 studies published in the January 8Lancet Infectious Diseases. However, there was no increase in risk for women using birth control pills.

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