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ICAAC 2014: IRIS and Risk of Early Death Among HIV+ People with Tuberculosis

People coinfected with HIV and tuberculosis (TB) who go onto develop immune reconstitution inflammatory syndrome (IRIS) while on antiretroviral therapy (ART) have a pre-ART immunological profile that is easily distinguishable from those who are at risk of early mortality despite being treated for both HIV and TB, according to a presentation at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy this month in Washington, DC.

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Obama Signs Executive Order to Fight Antibiotic-Resistant Bacteria

President Barack Obama last week issued an executive order outlining measures to reduce the emergence and spread of antibiotic-resistant bacteria and to help ensure continued availability of effective treatments for drug-resistant infections. The order was released along with a report on Combatting Antibiotic Resistance by the President’s Council of Advisors on Science and Technology and a new National Strategy on Combating Antibiotic Resistant Bacteria.

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ICAAC 2014: Attempt to Shorten Standard Tuberculosis Treatment Fails in REMoxTB Trial

Two 4-month treatment regimens containing moxifloxacin were less effective than the standard 6-month regimen for drug-sensitive tuberculosis (TB), even though they produced a more rapid decline in bacterial load, according to results from the REMoxTB trial, which were presented in a poster session at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy this week in Washington, DC, and published simultaneously in the September 7 New England Journal of Medicine.

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ICAAC 2014: Antibiotic Stewardship Programs Reduce Use and Improve Outcomes

Programs to promote appropriate use of antibiotics in hospitals and other healthcare facilities can help reduce use of these drugs and thereby ameliorate the risk of developing resistance, researchers reported at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy last week in Washington, DC.

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AIDS 2014: Young People with HIV Respond Well to Human Papillomavirus Vaccine

The quadrivalent human papillomavirus (HPV) vaccine worked as well for teens and young adults with HIV as it did for their HIV negative counterparts, according to study findings presented the 20thInternational AIDS Conference last week in Melbourne.

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ICAAC 2014: Delafloxacin Shows Promise as a Single-dose Treatment for Gonorrhea

A new antibiotic, delafloxacin, demonstrated potent activity against gonorrhea -- including drug-resistant strains -- in a laboratory study, and its pharmacokinetics suggest that single-dose oral treatment will be feasible, according to research presented at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy this week in Washington, DC.

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AIDS 2014: Novel PaMZ Tuberculosis Regimen Could Reduce Treatment Duration

A novel tuberculosis (TB) drug regimen could treat drug-sensitive and some forms of drug-resistant TB far more quickly than current standard therapy, according to findings from a Phase 2b trial presented today at the 20th International AIDS Conference (AIDS 2104) in Melbourne, Australia.

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ICAAC 2014: Single Dose of Flu Drug Peramavir Looks Safe and Effective

A single dose of the investigational neuraminidase inhibitorperamavir (Rapivab) administered within 2 days after symptom onset lowered influenza viral load and reduced duration of symptoms including fever, according to study findings presented at the the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy this week in Washington, DC.

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WHO Announces Plan to Eliminate Tuberculosis in Low-incidence Countries

The World Health Organization (WHO) and the European Respiratory Society (ERS) last week introduced a new framework for the elimination of tuberculosis (TB) in more than 30 low-incidence countries, which includes most of Western Europe, the U.S., Canada, and Australia.

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