|
|
 |
|
| •
|
Abnormalities
of glucose homeostasis (primarily insulin resistance) are common
in patients on HAART |
| •
|
Higher
incidence is in patients receiving PIs
|
| •
|
Mechanisms
remain unclear at this time |
| •
|
Treatment
with insulin-sensitizing agents may be beneficial |
|
|
• In conclusion, it is common to find abnormalities in glucose
metabolism in patients receiving HAART. Although various conditions
have been documented, the one most commonly observed is insulin resistance.
• It also appears that patients receiving protease inhibitors
have a higher incidence of these disorders.
• The mechanisms behind these abnormalities remain unclear at
this time. Various drugs, central adiposity, and triglyceride levels
seem to play some role.
• The treatment for HIV-infected patients with these conditions
is the same as for non-HIV-infected patients. Various therapeutic
agents, including insulin-sensitizing agents, may be beneficial when
used alone or in combination.
• Additional research is needed to understand these syndromes
more thoroughly in patients with HIV infection.
|
|
|
|
