- Category: HIV/HCV Coinfection
- Published on Monday, 21 November 2016 00:00
- Written by Liz Highleyman
More than 90% of HIV-positive people treated with direct-acting antivirals for hepatitis C -- including many with liver cirrhosis -- achieved sustained virological response and few discontinued treatment due to side effects, showing that real-world clinical practice can produce results as good as those seen in formal clinical trials, according to results from a Spanish study presented at the AASLD Liver Meeting this month in Boston.
HIV-positive people coinfected with hepatitis C virus (HCV) experience more rapid liver disease progression, on average, and did not respond as well as HIV-negative people to interferon-based hepatitis C treatment.
New direct-acting antivirals (DAAs) used in interferon-free regimens have made treatment simpler, better-tolerated, and much more effective. Clinical trials showed that DAAs work as well for HIV-positive as for HIV-negative people with hepatitis C -- so well that coinfected people are no longer considered a "special population" -- although they need to be aware of potential drug-drug interactions with antiretrovirals. But outcomes in real-life clinical practice sometimes do not match those of formal drug trials in which participants are carefully selected and may receive more intensive monitoring and support.
Juan Gonzalez-García from Hospital La Paz and colleagues evaluated treatment outcomes in the Madrid Coinfection Registry (Madrid-CoRe), a prospective registry of all HIV/HCV coinfected individuals receiving DAA-based hepatitis C treatment at hospitals of the Madrid Regional Health Service, which are required to register their coinfected patients.
The analysis included 2030 coinfected adults who started treatment between November 2014 and May 2016 and who completed therapy and had long enough follow-up to determine sustained virological response, or continued undetectable HCV viral load at 12 weeks post-treatment (SVR12). Relapse was defined as a rebound of HCV RNA levels after the end of treatment.
Nearly 80% of patients in the registry were men and the mean age was 50 years. Most (95%) were on combination antiretroviral therapy and the median CD4 T-cell count was high, at 570 cells/mm3. The most common HCV genotype was 1a (40%), followed by genotype 4 (22%), genotype 1b (16%), and genotype 3 (15%).
More than half (55%) were non-cirrhotic, but 37% had compensated cirrhosis and 7% had decompensated liver disease; 7% had experienced severe extra-hepatic manifestations of HCV infection. In addition, 15 people had a history of hepatocellular carcinoma, 17 had undergone liver transplantation, and 7 were on a transplant waiting list.
Over 60% were being treated for hepatitis C for the first time. Nearly a third included ribavirin in their regimen. The most common DAA regimen was sofosbuvir/ledipasvir (Harvoni), used by 63%, followed by sofosbuvir (Sovaldi) plus daclatasvir (Daklinza) and the paritaprevir-based "3D" regimen (Viekira Pak), both at 15%. Smaller numbers used the paritaprevir "2D" regimen (Technivie), sofosbuvir plus simeprevir (Olysio), or sofosbuvir plus ribavirin.
- The overall SVR12 rate in an intention-to-treat analysis was 92.0%.
- Cure rates were similar across HCV genotypes: 92.2% for genotype 1a, 93.5% for 1b, 91.9% for genotype 3, and 90.4% for genotype 4.
- SVR12 rates were 93.7% for non-cirrhotic patients and 91.5% for those with compensated cirrhosis, but declined to 80.8% for those with decompensated liver disease.
- Cure rates were good for patients without cirrhosis regardless of genotype (92.6%-96.4%), but dropped for people with compensated cirrhosis (88.0%-93.8%) and especially for those with decompensated cirrhosis (77.3%-87.5%).
- Cirrhotic patients with genotype 1a (77.5%) or 3 (77.3%) had the lowest sustained response rates.
- 5 people (0.2%) experienced viral breakthrough while on treatment and 89 (4.4%) experienced post-treatment relapse.
- 14 patients (0.7%) discontinued treatment due to adverse events and 36 (1.8%) did so for other reasons.
- 19 people (0.9%) died during treatment or follow-up, 17 of whom had cirrhosis.
- In a multivariate analysis, the only significant predictors of treatment failure were having decompensated cirrhosis -- but not compensated cirrhosis -- and use of certain DAA regimens (sofosbuvir plus simeprevir, sofosbuvir plus ribavirin, or simeprevir plus daclatasvir).
"In this large prospective cohort of HIV/HCV coinfected persons, 45% of whom had liver cirrhosis, the SVR12 [rate] of DAA-based therapy for HCV infection was >90%," the researchers concluded, and <1% discontinued therapy due to adverse events.
These results confirm that treatment outcomes are similar for HIV/HCV coinfected patients and people with HCV alone, Gonzalez-García said, adding that the lower response rate for people with decompensate liver disease is a reason to start treatment earlier.
In response to a question, he said the researchers did not have genotypic data from people with virological failure that could determine whether they experienced relapse or HCV reinfection.
A Gil-Martin, JJ Gonzalez-García, E Cruz-Martos, et al. Real-world Outcomes with New HCV Antivirals in HIV/HCV-coinfected Subjects: Madrid Coinfection Registry (Madrid-CoRE) Findings. AASLD Liver Meeting. Boston, November 11-15, 2016. Abstract 78.