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EASL 2016: Core Inhibitor NVR 3-778 Plus Pegylated Interferon Inhibits Hepatitis B Activity

NVR 3-778, an experimental drug that interferes with hepatitis B virus (HBV) capsid assembly, led to reductions in HBV DNA, HBV RNA, and hepatitis B "e" antigen (HBeAg), showing greater activity when combined with pegylated interferon, researchers reported at the European Association for the Study of the Liver's International Liver Congress (EASL 2016) this month in Barcelona.

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EASL 2016: Tenofovir Alafenamide Works Well Against Hepatitis B with Less Effect on Bones and Kidneys

The new tenofovir alafenamide (TAF) pro-drug is as potent against hepatitis B virus (HBV) as the current tenofovir disoproxil fumarate (TDF) formulation, but with less detrimental effects on bone and kidney biomarkers, according to a pair of studies presented at the European Association for the Study of the Liver's International Liver Congress (EASL 2016) last week in Barcelona.

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Chinese Herbs Taken with Lamivudine May Reduce Hepatitis B Mortality

Hepatitis B patients who used traditional Chinese medicine, including the herbal preparation Jia-Wei-Xiao-Yao-San, while being treated with lamivudine (3TC or Epivir) were less likely to die of any cause than non-users, according to research published in the November 4, 2015, Journal of Enthopharmacology.

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AASLD 2015: Hepatitis B Core Inhibitor NVR 3-778 Inhibits Viral Replication

Novira Therapeutics' NVR 3-778, a novel drug that interferes with the hepatitis B virus (HBV) core protein, blocked replication of various types of HBV in a laboratory study and reduced HBV viral load with no apparent safety issues in an early human trial, researchers reported at the AASLD Liver Meeting in November.

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Tenofovir Alafenamide Is Effective Against Hepatitis B with Less Kidney and Bone Toxicity

A pair of Phase 3 studies have shown that Gilead Sciences' new tenofovir alafenamide (TAF) suppresses hepatitis B virus (HBV) as well as the current tenofovir disoproxil fumarate (TDF) formulation, but with less detrimental effects on the kidneys and bones, the company announced this week.

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