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Does Human Papillomavirus Contribute to Lung Cancer?

A small proportion of lung cancers may be caused by the same high-risk strains of human papillomavirus (HPV) associated with cervical and anal cancer, according to recently reported study findings, which could help explain an apparent link between higher lung cancer rates and immune deficiency in people with HIV.


CROI 2013: Random Anal Biopsies Improve Detection of Pre-cancerous Lesions

Performing random anal biopsies increases the rate of diagnosis of high-grade squamous intraepithelial lesions (HSIL) during high-resolution anoscopy, researchers from Mt. Sinai School of Medicine in New York City reported at the recent 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013).alt

ICAAC 2012: Progression of Anal Neoplasia is Common among Gay Men with HIV

Nearly 40% of HIV positive men with low-grade anal neoplasia may progress to high-grade neoplasia or anal cancer, according to a Spanish study presented at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) this week in San Francisco. Younger age and shorter duration of HIV infection were risk factors for worsening disease.alt

CROI 2013: Researchers Look at Neurological Complications among People with HIV

Data from a small, yet well-designed trial to evaluate whether particular antiretroviral therapy (ART) regimens penetrate the central nervous system (CNS) and enhance neurocognitive performance were among several interesting findings regarding neurological complications among people with HIV presented at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) this month in Atlanta. Another study looked at similarities between Alzheimer's disease and neurocognitive impairment in people with HIV.


AIDS 2012: Human Papillomavirus Doubles Risk of HIV infection

Pre-existing human papillomavirus (HPV) infection is associated with a 2-fold increase in the risk of HIV acquisition in women, and risk also rose for both heterosexual and gay/bisexual men, according to an 8-study review presented at the recent XIX International AIDS Conference (AIDS 2012) in Washington, DC, and published in the August 7, 2012, advance online edition of AIDS.alt

CROI 2013: Statins for People with HIV -- How Sweet Is It?

Statins may help reduce co-morbid conditions such as cardiovascular disease and lower mortality for some people with HIV, but with a possible trade-off of higher diabetes risk, according to a series of studies presented and discussed at 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) this month in Atlanta.


HPV Vaccine Provides Herd Immunity to Unvaccinated Women

The human papillomavirus (HPV) vaccine can offer protection to girls and young women who did not themselves undergo immunization, a phenomenon known as "herd immunity," according to a study published in the July 9, 2012, advance online edition of Pediatrics. Widespread immunity against high-risk altHPV types 16 and 18 may result in lower rates of cervical and anal cancer in years to come.

CROI 2013: HIV+ Men at Increased Risk for Co-morbid Conditions Regardless of Age

 Men with HIV in a large cohort of U.S. veterans were more likely to develop cardiovascular disease, end-stage kidney disease, and certain cancers compared with HIV negative people, but not at earlier ages, according to a report presented at the 20th Conference on Retroviruses and Opportunistic Infections this month in Atlanta.


Chronic Gum Disease Linked to HPV-related Head and Neck Cancers

Chronic periodontitis, or inflammation of the gums, is associated with a great risk of squamous cell carcinomas of the mouth and throat that contain human papillomavirus (HPV), according to a study published in the June 18, 2012, advance online edition of Archives of Otolaryngology - Head and Neck Surgery.alt

CROI 2013: Heart Disease Rises Only Slighter Faster with Age for People with HIV

The risk of cardiovascular disease among HIV positive men in D:A:D rose from age 40-45 to 60-65, but only slightly more rapidly than in the general population,researchers reported at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) last week in Atlanta. A related analysis found that the likelihood of death after a heart attack has fallen over time.


Researchers Identify Origin of Cervical Cancer Caused by Human Papillomavirus

Researchers have identified a population of cells in the uterine cervix that appears to give rise to dysplasia and cancer caused by human papillomavirus (HPV), according to a report in the June 11, 2012, Proceedings of the National Academy of Sciences.alt

CROI 2013: Cancer Incidence After Starting Antiretroviral Therapy [VIDEO]

Rates of AIDS-related cancers start to fall not long after initiation of antiretroviral therapy (ART), but non-AIDS cancers rise with increasing time on therapy, according to study findings presented last week at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta.


ASCO 2012: Treatment of Anal Cancer in People with HIV

HIV positive people may experience more aggressive anal cancer progression and require prompt diagnosis, researchers reported at the American Society of Clinical Oncology Annual Meeting (ASCO 2012) taking place this week in Chicago. A related study found that quadruple combination anal cancer therapy is safe and may be effective for both HIV positive and negative patients.


U.S. Cancer Rates Fall Overall, but Some HPV-associated Cancers Rise

Deaths due to all types of cancer combined decreased for men and women of all racial/ethnic groups in the U.S., according to a joint "Annual Report to the Nation," published in the January 7, 2013, advance edition of the Journal of the National Cancer Institute. Incidence of oral and anal cancer increased, however, leading the report authors to call for wider use of human papillomavirus (HPV) vaccines.


Researchers Identify Compounds that May Block HPV's Ability to Cause Cancer

Researchers have identified a set of compounds known as thiadiazolidinediones that interfere with the ability of human papillomavirus (HPV) to disable a key tumor suppressor protein, offering a potential new approach to treatment, according to a report in the April 20, 2012, issue of Chemistry & Biology. alt

Human Papillomavirus Vaccination Can Protect Many Women with HIV

HIV positive women may benefit from immunization against cancer-causing human papillomavirus (HPV) types, even though they are likely to have been exposed to some types of the virus previously, according to a study in the November 1, 2012, Journal of Acquired Immune Deficiency Syndromes. A majority of study participants remained susceptible to the most common high-risk types, HPV-16 and HPV-18.alt

CROI 2012: Electrocautery Superior to Imiquimod or 5-Fluorouracil for Treatment of Anal Neoplasia

Electrocautery was shown to be more effective and tolerable than topical imiquimod or 5-fluorouracil as a treatment for anal intraepithelial neoplasia (AIN) in HIV positive men who have sex with men (MSM), researchers reported in a late-breaker presentation at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) last week in Seattle.alt

Topical Cidofovir Effective and Well-tolerated for Anal and Vulva Neoplasia

A topical formulation of the antiviral drug cidofovir (Vistide), best known as a treatment for cytomegalovirus (CMV), also appears effective for short-term treatment of high-grade anal and vulva cancer caused by human papillomavirus (HPV) in people with HIV, according to a report in the October 1, 2012, advance online edition of AIDS. alt

Electrocautery Prevents Progression to Anal Cancer in HIV Positive and Negative Gay Men

Electrocautery ablation to remove abnormal tissue significantly reduced the likelihood of progression to anal cancer for both HIV positive and HIV negative gay men with high-grade anal intraepithelial neoplasia, according to a study described in the November 30, 2011, advance online edition of the Journal of Acquired Immune Deficiency Syndromes.alt

HIV Is a Major Contributor to Increase in Anal Cancer among U.S. Men

Increased incidence of anal cancer during the past 3 decades among men in the U.S. has been strongly influenced by the HIV epidemic, although a similar association was not observed for women, researchers reported in the October 5, 2012, advance edition of the Journal of the National Cancer Institute. alt

AASLD 2011: High Rate of Cancer-Causing HPV among Women with Hepatitis C Awaiting Liver Transplants

Nearly 1 in 5 women undergoing liver transplantation -- most of them due to chronic hepatitis C virus (HCV) infection -- were also infected with cancer-causing types of human papillomavirus (HPV), even though their behavioral risk was low, researchers reported at the American Association for the Study of Liver Diseases Liver Meeting (AASLD 2011) this week in San Francisco. alt