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AASLD 2017: Experimental NASH Therapy Improves Liver Fat and Fibrosis

GS-0976, an acetyl-CoA carboxylase (ACC) inhibitor being developed by Gilead Sciences, led to significant reductions in liver fat accumulation and fibrosis in people with non-alcoholic steatohepatitis (NASH), according to Phase 2 study results presented at the 2017 AASLD Liver Meeting last week in Washington, DC.

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Cenicriviroc May Reduce Fibrosis in People with Fatty Liver Disease

Cenicriviroc, a drug that blocks both CCR5 and CCR2 receptors on immune cells, was associated with a decrease in liver fibrosis in people with non-alcoholic steatosis, a type of fatty liver disease, according to a report in the August 17 online edition of Hepatology.

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EASL 2016: NorUrsodeoxycholic Acid Help Rare Bile Duct Disease with No Current Treatment

A Phase 2 European trial showed that norUrsodeoxycholic acid leads to a significant reduction in serum alkaline phosphatase in people with primary sclerosing cholangitis (PSC), a rare but serious bile duct disease, according to a report presented at the European Association for the Study of the Liver's International Liver Congress (EASL 2016) last week in Barcelona.

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EASL 2017: Norfloxacin Reduces Risk of Death for People with Decompensated Cirrhosis

Long-term prophylaxis with the antibiotic norfloxacin significantly reduced the incidence of death in people with decompensated cirrhosis over a 6-month follow-up period, according to a French randomized trial reported at the EASL International Liver Congress this week in Amsterdam.

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EASL 2015: Milk Thistle May Improve Steatohepatitis, Capsaicin from Chili Peppers Helps Fibrosis

People who used silymarin, derived from the milk thistle plant, experienced a resolution of non-alcoholic steatohepatitis (NASH) and a reduction in liver fibrosis in a randomized, placebo-controlled trial, researchers reported at the European Association for the Study of the Liver (EASL) 50th International Liver Congress last month in Vienna. Another study found that dietary capsaicin, derived from chili peppers, was associated with improvement in mice with artificially induced fibrosis, the precursor to cirrhosis.

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AASLD 2016: When You Eat May Contribute to Fatty Liver Disease as Much as What You Eat

People who skip breakfast and eat late at night may have an elevated risk of non-alcoholic fatty liver disease (NAFLD), according to research presented at the AASLD Liver Meeting this week in Boston. This suggests that meal timing and frequency of meals may be modifiable risk factors for fatty liver disease, which can lead to cirrhosis and liver cancer.

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EASL 2015: Heavy Drinkers Contribute Most to Liver Cirrhosis Burden; Heavy Alcohol Use Rising in U.S.

The number of people who regularly consume more than a moderate amount of alcohol is a better indicator of alcoholic cirrhosis prevalence than per capita annual consumption, or the total amount consumed per year divided by the entire population, according to a presentation at the European Association for the Study of the Liver (EASL) 50th International Liver Congress last month in Vienna. A related study found that heavy drinking and binge drinking have risen over the past decade in the U.S., largely due to increases among women.

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EASL 2016: Emricasan May Improve Inflammation and Liver Function in People with Cirrhosis

The novel caspase inhibitor emricasan (IDN-6556) led to improvements in various biomarkers and decreases in MELD scores in patients with liver cirrhosis due to hepatitis C, heavy alcohol use, or other causes, which significant declines among those who started with worse liver dysfunction, according to a late-breaking presentation at the European Association for the Study of the Liver's International Liver Congress (EASL 2016) last week in Barcelona.

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Coffee Helps Protect Against Liver Cancer, Obesity Confirmed as Risk Factors

Drinking coffee regularly may help prevent development of liver cancer, according to a systemic research review of 34 studies with more than 8 million total participants conducted by the World Cancer Research Fund's Continuous Update Project (CUP). The analysis also found that being overweight and heavy alcohol consumption are major risk factors for liver cancer.

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