Coinfection

Treatment of HIV/HCV Coinfected People with Compensated Liver Cirrhosis

HIV positive people with compensated liver cirrhosis related to chronic hepatitis C virus (HCV) responded as well to treatment with pegylated interferon and ribavirin as coinfected patients without cirrhosis, but they should receive closer monitoring and may need more intensive management of side effects. alt

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IAS 2011: Maraviroc Improves Liver Fibrosis in HIV/Hepatitis C Coinfected Patients

Treatment with maraviroc is associated with the regression of liver fibrosis in HIV-positive patients co-infected with hepatitis C, a small randomised study presented to the Sixth International AIDS Society conference (IAS 2011) in Rome shows.alt

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Viral Load, HIV Status, but not IL28B Predict Perinatal HCV Transmission

Women with higher HCV viral load and those coinfected with HIV were more likely to transmit HCV to their babies in a recent Spanish study. IL28B gene pattern did not affect transmission directly, but babies with the favorable CC pattern more often spontaneously cleared HCV.

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IAS 2011: Transplants Safe for HIV+ People but HCV Adds Risk

Kidney and Liver transplants can be safe and effective for people living with HIV. However hepatitis C virus (HCV) coinfection and several other factors may make such procedures more risky. alt

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Treatment Interruption Spurs Fibrosis in HIV/HCV Coinfected People

Stopping antiretroviral therapy led to liver fibrosis progression in HIV/HCV coinfected people, an effect that was not fully attributable to increased HIV viral load or reduced CD4 cell count.

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Gene Patterns Predict Fibrosis in HIV/HCV Coinfected People

Certain haplogroups, or gene pattern clusters, were associated with reduced risk of liver fibrosis among European patients with HIV and hepatitis C coinfection.

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EASL 2011: HIV/HCV Coinfection among HIV Positive Gay Men

Researchers at EASL presented further data on outbreaks of sexually transmitted HCV among HIV positive men who have sex with men. Sustained response rates are high when interferon-based therapy is started during acute infection, but re-infection after treatment is common in this population. alt

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HIV/HCV Coinfected Have Stronger CD8 T-cell Response to HCV

HIV positive people coinfected with hepatitis C virus (HCV) demonstrated stronger CD8 T-cell responses against HCV, which may contribute to accelerated liver disease progression.

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EASL 2011: Liver Disease Progression in HIV/HCV Coinfected People

Liver stiffness measured by FibroScan is a good predictor of liver cancer, end-stage liver disease or death among people with HIV/HCV coinfection, researchers reported as EASL 2011.

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