Other Infections

AASLD 2013: HCV Levels in Semen May Correspond to Blood Viral Load

HIV positive men with higher hepatitis C virus (HCV) RNA levels in their blood during acute infection were more likely to have HCV in their semen as well, which may raise the risk of sexual transmission, researchers reported last month at the 64thAASLD Liver Meeting in Washington, DC.

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AASLD 2013: Tenofovir for Hepatitis B Remains Safe and Effective Over 7 Years

Chronic hepatitis B patients treated with tenofovir (Viread) for 7 years continued to main viral suppression and liver enzyme normalization, while serological response rates continued to increase, according to a poster presented at the 64th AASLD Liver Meeting last month in Washington, DC. Long-term kidney and bone-related side effects remained uncommon.

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AASLD 2013: Faldaprevir Triple Therapy Effective Across Patient Subgroups

The experimental hepatitis C virus (HCV) protease inhibitor faldaprevir in combination with pegylated interferon and ribavirin was effective across a range of subgroups of patients with genotype 1 infection -- including prior relapsers and non-responders -- in the STARTVerso clinical trials program, according to research presented at the recent AASLD Liver Meeting in Washington, DC.

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AASLD 2013: MK-5172 + Ribavirin Works Well for People with Hepatitis C Genotype 1b

An interferon-free regimen consisting of Merck's next-generation hepatitis C virus (HCV) protease inhibitor MK-5172 plus ribavirin led to high rates of viral suppression and promising early cure rates for patients with HCV subtype 1b, according to a poster presented at the 64thAASLD Liver Meeting last month in Washington, DC.

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AASLD 2013: Aspirin and Cenicriviroc May Help Reduce Liver Fibrosis

Hepatitis C patients who took low-dose aspirin after liver transplantation experienced slower fibrosis progression, researchers reported at the AASLD Liver Meeting this month in Washington, DC. Two other studies showed that cenicriviroc -- a drug being developed for HIV treatment that blocks both CCR5 and CCR2 cell surface receptors -- had anti-inflammatory and anti-fibrotic activity in mice and rats.

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AASLD 2013: Sofosbuvir + Ribavirin Effective Against Hepatitis C Genotype 4

A dual oral regimen of sofosbuvir plus ribavirin taken for 24 weeks led to an early cure at 4 weeks post-treatment for difficult-to-treat patients with hepatitis C virus (HCV) genotype 4, according to a poster presented at the 64th AASLD Liver Meeting last month in Washington, DC.

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AASLD 2013: Liver Meeting Ends with Hepatitis C Debrief and the Future of Treatment

The final day of AASLD Liver Meeting, recently held in Washington, DC, featured an overview of the status of new hepatitis C therapies, similarities between HCV and HIV, and a look towards the future of hepatitis C treatment. The development of next-generation HCV drugs has been remarkably rapid and experts agree that it may soon be possible to cure all patients with hepatitis C, but access is likely to be a challenge.

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AASLD 2013: Viral Hepatitis Epidemics in the U.S. and California

Deputy Assistant Secretary for Health Ronald Valdisseri described the hepatitis B and C epidemics in the U.S., the HCV cascade of care, and efforts to combat viral hepatitis at the AASLD Liver Meeting this month in Washington, DC. Public health officials in California also recently released a report on the hepatitis B and C epidemics in that state.

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AASLD 2013: Faldaprevir All-oral Regimen Shows 100% Early Sustained Response for HCV 1a

An interferon-free regimen of faldaprevir, deleobuvir, and PPI-668 led to 4-week post-treatment sustained virological response (SVR4) in all treatment-naive patients with hard-to-treat HCV subtype 1a in an ongoing Phase 2 trial, according to a late-breaking poster presentation at the 64th AASLD Liver Meeting this month in Washington, DC.

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