HCV Basic Science
NS5A Inhibitor Daclatasvir Has Dual Mode of Action Against Hepatitis C Virus
- Details
- Category: HCV Treatment
- Published on Wednesday, 20 February 2013 00:00
- Written by Loyola
The promising investigational hepatitis C virus (HCV) NS5A inhibitor daclatasvir targets 2 steps of the viral replication process, enabling very rapid HCV RNA reduction, according to a mathematical model described in the February 19, 2013, advance edition of Proceedings of the National Academy of Sciences.
IRES Inhibitor Discovery May Offer New Way to Halt Hepatitis C Replication
- Details
- Category: Experimental HCV Drugs
- Published on Tuesday, 20 March 2012 00:00
- Written by Press Release
Researchers have discovered the structure of a molecule from a class of compounds called benzimidazoles that can attach itself to the internal ribosome entry site (IRES) in the genetic material of hepatitis C virus (HCV) and stop its replication, according to a report in the March 19, 2012, advance online edition of Proceedings of the National Academy of Sciences USA.
Hepatitis A Immune Response Has Implications for Hepatitis C
- Details
- Category: HCV Basic Science
- Published on Friday, 08 July 2011 13:19
- Written by Tad Kepley
Hepatitis A virus appears to evade immune defenses better than hepatitis C virus, even though it only causes short-term illness. Learning about differences between viral dynamics and immune response to HAV and HCV may offer information that can inform treatment.
Researchers Show How Cholesterol Receptor Promotes HCV Cell Entry
- Details
- Category: HCV Basic Science
- Published on Friday, 27 January 2012 00:00
- Written by Press Release
A molecule in liver cell membranes that plays a role in cholesterol uptake also enables hepatitis C virus (HCV) to enter cells, according to research reported in the January 8, 2012, advance online edition of Nature Medicine.
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