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HCV Basic Science

Trio of Broadly Neutralizing Antibodies Interfere with Hepatitis C Virus Infection

Three broadly neutralizing antibodies delivered by a viral vector blocked hepatitis C virus (HCV) infection of hepatocytes (liver cells) in a laboratory culture model and appeared to cure infection in modified mice carrying human liver tissue, researchers reported in the September 17 edition of Science Translational Medicine.

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Study Sheds Light on How Hepatitis C Virus Evades Immune System

Hepatitis C virus (HCV) appears to disable a specific variant of the IFNL3 gene, which plays a role in the immune system's response against viral infection, explaining how people with a favorable gene pattern are more likely to clear the virus naturally or with interferon-based treatment, researchers reported in the January 2014 issue of Nature Immunology.

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IRES Inhibitor Discovery May Offer New Way to Halt Hepatitis C Replication

Researchers have discovered the structure of a molecule from a class of compounds called benzimidazoles that can attach itself to the internal ribosome entry site (IRES) in the genetic material of hepatitis C virus (HCV) and stop its replication, according to a report in the March 19, 2012, advance online edition of Proceedings of the National Academy of Sciences USA.alt

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NS5A Inhibitor Daclatasvir Has Dual Mode of Action Against Hepatitis C Virus

The promising investigational hepatitis C virus (HCV) NS5A inhibitor daclatasvir targets 2 steps of the viral replication process, enabling very rapid HCV RNA reduction, according to a mathematical model described in the February 19, 2013, advance edition of Proceedings of the National Academy of Sciences.

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Researchers Show How Cholesterol Receptor Promotes HCV Cell Entry

A molecule in liver cell membranes that plays a role in cholesterol uptake also enables hepatitis C virus (HCV) to enter cells, according to research reported in the January 8, 2012, advance online edition of Nature Medicine.alt

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