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Grazoprevir/Elbasvir Hepatitis C Treatment Works Wells for People Who Inject Drugs

Merck's grazoprevir/elbasvir hepatitis C regimen was well-tolerated and cured more than 90% of injection drug users receiving opioid substitution therapy, according to results from the C-EDGE CO-STAR study published in the August 9 online edition of Annals of Internal Medicine. The investigators reported that adherence was good even though many study participants continued to use illicit drugs.

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FDA Approves Once-Daily Coformulation of AbbVie's Viekira Regimen

The U.S. Food and Drug Administration (FDA) has approved a new once-daily coformulation of AbbVie's paritaprevir-based "3D" regimen for hepatitis C virus (HCV) genotype 1, to be sold as Viekira XR, the company announced this week. AbbVie also said that the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has given a positive opinion on a shorter 12-week course of treatment with Viekirax for HCV genotype 4 patients with liver cirrhosis.

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AASLD/IDSA Hepatitis C Guidelines Updated to Include New Therapies

The American Association for the Study of Liver Diseases, Infectious Diseases Society of America, and International Antiviral Society-USA this week updated their hepatitis C guidelines to add newly approved direct-acting antiviral (DAA) regimens, offering more options for people with HCV genotypes other than 1 or 4. The full guidance is available online at HCVguidelines.org.

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Coverage of 21st International AIDS Conference (AIDS 2016)

HIVandHepatitis.com coverage of the 21st International AIDS Conference (AIDS 2016), held July 18-22, in Durban, South Africa.

Conference highlights include PrEP and other biomedical HIV prevention, HIV cure research, experimental antiretroviral therapy, and access to treatment and prevention for key affected populations.

Full listing by topic

AIDS 2016 website

7/28/16

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FDA Approves Gilead's Epclusa Combo Pill for All Hepatitis C Genotypes

On June 28 the U.S. Food and Drug Administration (FDA) approved Gilead Sciences Epclusa, a new once-daily combination pill containing sofosbuvir and velpatasvir, for the treatment of adults with hepatitis C virus (HCV) genotypes 1 through 6 -- the first approved oral pangenotypic regimen. While it is more effective against more types of HCV, Epclusa will cost less than most earlier interferon-free direct-acting antiviral regimens.

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