Back Hepatitis C

Hepatitis C

FDA Will Consider Approval of Daclatasvir for Genotype 3 Hepatitis C Treatment

The U.S. Food and Drug Administration (FDA) has accepted Bristol-Myers Squibb's application for approval of stand-alone daclatasvir (Daklinza) for the treatment of genotype 3 hepatitis C virus (HCV), to be used in combination with sofosbuvir (Sovaldi), the company announced last week.

alt

CROI 2015: Re-infection Due to Ongoing Risk Is Probably the Cause of HCV Recurrence After SVR

Rates of hepatitis C virus (HCV) recurrence after successful therapy differ markedly between risk groups, according to the results of a meta-analysis presented at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.

alt

New Hepatitis C Treatments Highly Effective for HIV/HCV Coinfected People

A pair of interferon-free combinations -- AbbVie's 3-drug Viekira Pak regimen and Gilead Science's sofosbuvir/ledipasvir (Harvoni) -- demonstrated good safety and cured more than 90% of genotype 1 HIV/HCV coinfected people, according to studies published in the February 23 advance edition of the Journal of the American Medical Association.

alt

CROI 2015: Sustained Virological Response Represents a Long-term Cure for Hepatitis C

Almost all patients with hepatitis C virus alone or HIV/HCV coinfection who achieved sustained virological response (SVR) to treatment with sofosbuvir (Sovaldi) plus ribavirin or sofosbuvir/ledipasvir (Harvoni) still had undetectable HCV RNA up to 2.4 years later, confirming that SVR represents a cure, according to a poster presented at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.

alt

CROI 2015: Hepatitis C -- A Light at the End of the Tunnel [VIDEO]

Charles Rice from the Rockefeller University traced the development of scientific knowledge about hepatitis C virus and the evolution of its treatment in a plenary lecture at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) taking place this week in Seattle.

alt

CROI 2015: Hepatitis C -- Mission Accomplished? [VIDEO]

New interferon-free treatment for hepatitis C virus (HCV) has brought about a revolution in treatment, but challenges still remain -- among them too few people with HCV being diagnosed and the high cost of the new drugs -- before the mission can be declared a success. A panel of hepatitis C experts discuss research presented at the recent 2015 Conference on Retroviruses and Opportunistic Infections(CROI) in Seattle with HIVandHepatitis.com editor Liz Highleyman in this IFARA video.

alt

AbbVie Dual Regimen Highly Effective Against HCV Genotype 1b

A 2-drug combination consisting of AbbVie's ritonavir-boosted HCV protease inhibitor parataprevir and NS5A inhibitor ombitasvir -- part of the Viekira Pak regimen -- demonstrated a 95% cure rate for people with hepatitis C virus genotype 1b, the most common type in Japan, according to a recent company announcement.

alt

CROI 2015: Liver Disease Progression Is Common Among Baby Boomers with Hepatitis C

The burden of hepatitis C virus (HCV) infection is high in the U.S., with nearly half of HCV-infected individuals born between 1945 and 1965 having severe fibrosis or cirrhosis and therefore being at high priority for treatment, according to a report presented at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle.

alt

Clinicians Report 2 Acute HCV Infections in Kaiser PrEP Program

Two HIV negative men gay receiving HIV pre-exposure prophylaxis (PrEP) through Kaiser Permanente in San Francisco were newly infected with hepatitis C virus (HCV), with sex being their only apparent risk factor, Kaiser clinicians reported in the February 18 issue of Clinical Infectious Diseases.

alt