- Category: HCV Treatment
- Published on Wednesday, 11 November 2015 00:00
A dual combination of Merck's grazoprevir and elbasvir taken for 12 or 16 weeks cured most HIV-positive people coinfected with hepatitis C virus (HCV) genotypes 1, 4, or 6, and was generally safe and well-tolerated, according to an integrated analysis of three trials presented at the recent IDWeek 2015 conference in San Diego.
- Category: HCV Policy & Advocacy
- Published on Tuesday, 10 November 2015 00:00
The Centers for Medicare & Medicaid Services last week issued a letter to state Medicaid programs stating that they are expected to cover new interferon-free antiviral therapies for hepatitis C without undue restrictions, as well as a letter to the pharmaceutical companies that make these drugs asking about purchasing arrangements to ensure wider access.
Even in the context of the relatively good access to harm reduction services in Australia, the principle reasons for people who inject drugs to reuse syringes relate to the convenience of services, the stigma of drug use, a fear of repercussions, and other contextual factors, according to a recent study. No participants reported sharing equipment as a choice -- if sterile equipment had been readily available at the time they needed it, they would have preferred to use it.
- Category: Experimental HCV Drugs
- Published on Monday, 02 November 2015 00:00
Gilead Sciences last week requested U.S. Food and Drug Administration (FDA) approval for a single-tablet regimen containing the hepatitis C virus (HCV) polymerase inhibitor sofosbuvir and the next-generation pangenotypic NS5A inhibitor velpatasvir, formerly known as GS-5816. Unlike the widely used sofosbuvir/ledipasvir (Harvoni), the new combination shows potent activity against HCV genotypes 1 through 6.
- Category: HCV Sexual Transmission
- Published on Sunday, 01 November 2015 00:00
Researchers have seen no decline in new hepatitis C virus (HCV) infections among HIV-positive men who have sex with men in 16 European CASCADE cohorts, according to a poster presented at the 15th European AIDS Conference last week in Barcelona. However, trends seem to differ between various regions of Europe.
While epidemiologists and public health experts are excited about the potential of new hepatitis C drugs to limit onward transmission of the virus among people who inject drugs, some strategies ignore profound barriers to drug users engaging with healthcare and their broader needs. For "treatment as prevention" to be ethical and acceptable to this people who inject drugs, enabling treatment and policy environments need to be created, according to reports at the 24th International Harm Reduction Conference last month in Kuala Lumpur.
- Category: HCV Treatment
- Published on Wednesday, 28 October 2015 00:00
Most hepatitis C patients in the GECCO German hepatitis C cohort who were treated with sofosbuvir/ledipasvir (Harvoni) for 8 weeks in a real-world clinical setting achieved sustained virological response, even those who are advised to stay on treatment for 12 weeks due to factors such as liver cirrhosis, prior treatment experience, and high HCV viral load, according to a presentation last week at the 15th European AIDS Conference in Barcelona.
A series of pilot projects in China, Indonesia, and Cambodia are showing that non-coercive, community-based drug treatment projects are feasible and more effective than the current approach of many Asian countries, incarceration and compulsory treatment, according to findings presented at the 24th International Harm Reduction Conference last month in Kuala Lumpur and in a report launched at the conference.
- Category: Injection Drug Use
- Published on Tuesday, 27 October 2015 00:00
The numbers of people injecting steroids and other image-enhancing drugs has increased significantly in the last decade, and harm reduction services need to develop new skills if they are to help people using these drugs avoid blood-borne viruses, according to presentations at the 24th International Harm Reduction Conference last week in Kuala Lumpur. Surveys in the UK suggest that rates of HIV and viral hepatitis infections are significantly higher among people using these drugs than in the general population.
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